Rh非D型新生儿溶血病17例临床分析

Clinical Analysis on 17 Cases of Hemolytic Disease of Neonates with Non- D Rh

目的探讨Rh非D血型系统新生儿溶血病的发生。方法对产前母亲血清具有不规则抗体,可疑Rh系统血型的患儿及母亲进行ABO和Rh血型鉴定,并对患儿进行直接抗人球蛋白试验、肝功、游离抗体实验及放散试验监测,用微柱凝胶间接抗人球蛋白试验对患儿及母亲血清进行不规则抗体鉴定。结果 17例新生儿Rh非D新生儿溶血患儿中检测出,抗-E10例(占58.8%),抗-Ec3例(占17.6%),抗-C2例(占11.8%),抗-Ce2例(占11.8%)。结论产前推广孕产妇Rh血型及不规则抗体筛查,早期积极诊断及抗溶血治疗,可减少胆红素脑病发生率并减少换血率。

Objective To discuss how the newborn get Non-D RH hemolytic disease. Methods 1. To identify the blood type for ABO＆RH with the neonates, whose mothers had Irregular antibodies before giving birth, also with their mothers;2. To monitor the Direct antiglobulin test , Hepatic function test, Free antibody test and Elution test to the neonates;3. To identify if the neonates and their mothers have Irregular antibodies by the Microcolumn gel indirect antiglobulin test to their serum. Results From 17 cases of Non-D RH hemolytic disease of Neonates：10 of them are Anti-E（ 58.8%）,3 of them are Anti-EC （ 17.6%）. 2 of them are Anti-C （ 11.8%）, and 2 of them are Anti-CE （11.8%）. Conclusion If we popularize this kind of test for Pregnant women to check if there is Irregular antibodies of RH of them, the diagnosis would be made in time and a Anti-hemolysis treatment would be processed. In this way we can reduce the possibility of Bilirubin encephalopathy and Blood transfusion.