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非稳定型亚甲胺基叶立德参与的1,3-偶极环加成反应合成新型5-取代噁唑烷衍生物

Syntheses of Novel Oxazolidine Derivatives by 1,3-Dipolar Cycloaddition Reaction by Unstabilized Azomethine Ylides
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摘要 以N-三甲基硅甲基苄胺,多聚甲醛和芳香醛为原料,磷酸为催化剂,经1,3-偶极环加成反应合成了6个5-取代噁唑烷衍生物(3a^3f,其中3c^3f为新化合物),收率57%~73%,转化率70%~90%,其结构经1H NMR,13C NMR和ESI-MS表征。 Six oxazolidine derivatives（ 3a - 3f,3c - 3f were novel compounds）,in yield of 57% -73% and conversion of 70% - 90%,were synthesized by 1,3-dipolar cycloaddition reaction from N-（ trimethylsilylmethyl） benzylamine,paraformaldehyde and aromatic aldehyde,using phosphoric acid as catalyst. The structures were characterized by1^ H NMR,13^ C NMR and ESI-MS.
作者 曾凡浩 徐亮
机构地区 四川大学华西药学院
出处 《合成化学》 CAS CSCD 2015年第6期522-524,共3页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(21472129)
关键词 N-三甲基硅甲基苄胺 1 3-偶极环加成反应 合成 噁唑烷衍生物 N-（trimethylsilylmethyl） benzylamine 1 3-dipolar cycloaddition reaction synthesis oxazolidine derivative
分类号 O626.23 [理学—有机化学]
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参考文献18

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二级参考文献14

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