摘要
目的 探讨阿仑膦酸钠对比格犬人工假体与骨界面间骨强度的影响.方法 选取12只成年比格犬制备人工假体模型,采用随机数字表法分成试验组和对照组,各6只.试验组给予口服阿仑膦酸钠,而对照组给予等量的安慰剂.12周后处死动物,取出含有人工假体的标本,进行生物力学检测.采用两独立样本t检验进行统计学分析.结果 试验组人工假体与骨界面间的拔出强度显著高于对照组,差异有统计学意义（P＜0.05）,试验组人工假体与骨界面间的扭转强度也高于对照组,差异有统计学意义（P＜0.05）.结论 阿仑膦酸钠能够显著增加人工假体与骨界面间的强度,进而预防了比格犬人工假体的松动.这对于预防和治疗人工关节的无菌性松动有好的指导意义.
Objective To investigate effect of alendronate on prevention of aseptic loosening prothesis.Method Twelve beagles which had been implanted a titanium plug in femur were divided into two groups randomly,one received alendronate,and the other placebo as control.After 12 weeks,all beagles were sacrificed.specimens of femur were studied by biomechanical test.Independent sample t test was used for statistical analyses.Results The pull-out strength of the experimental group was higher than that of the control （P 〈 0.05）,and the torsion strength was also higher in the experimental group（P 〈 0.05）.Conclusion The therapy of alendronate can change the bone strength,inhibit aseptic loosening of prosthesis in beagle and could be a good drug for the prevention and treatment of aseptic loosening prothesis.
出处
《国际外科学杂志》
2015年第5期314-316,F0003,共4页
International Journal of Surgery
