阿托伐他汀对非酒精性脂肪肝的治疗研究

EFFECTS OF ATORVASTATIN ON TREATMENT OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

目的探讨阿托伐他汀治疗非酒精性脂肪肝(NAFLD)的疗效。方法选择90例NAFLD患者均分两组。予治疗组患者阿托伐他汀10mg/d口服治疗6个月。对照组患者则予辛伐他汀20mg/d口服。所有患者均禁酒,改善饮食结构,进行中等量有氧运动,控制体重。结果治疗后治疗组临床症状、肝功能均获改善,治疗组ALT较前下降明显。B超和CT示脂肪肝程度减轻,血糖、血脂、体重指数较前下降(P<0.05)。其中总胆固醇下降程度治疗组优于对照组(P<0.05)。治疗组未出现不良反应。结论在饮食控制、加强运动等基本治疗基础上,阿托伐他汀治疗可有效改善NAFLD患者肝功能、血糖、血脂代谢,减轻脂肪肝程度,耐受好,不良反应少,选用阿托伐他汀治疗安全有效。

Objective To evaluate the efficacy and safety of atorvastatin in treatment of patients with , non-alcoholic fatty liver disease （NAFLD） .Methods Of 90 patients with NAFLD were divided into groups with 45 for each .The patients in trial group were orally received 10mg of atorvastatin for 6 month .The after therapy with simvastatin All patients were asked to take up basic therapy including drinking without alcohol ,restricting sugary and fatty intake ,improving food structure ,carrying moderate aerobics and lightening body weight .Results At the end of 6 months the clinical symptoms and the liver function amel-iorated in the patients groups ,the patients in trial group were presented with normal ALT levels .Ultra-sonic or CT examination showed that the steatchepatitits was improved significantly in the patients groups . Additionally ,the levels of blood glucose ,serum triglyceride and cholesterol as well as BMI decreased sim-ultaneously （ P〈0 .05） .Whereas the treatment group was superior to control group in aspect of ameliora-tion of inappetite ,nausea and vomiting as well as lever of serum cholesterol （ P 〈0 .05） .There was no side effect in the treatment group .Conclusion Based on the basic therapy ,atorvastatin can mitigate the de-gree of NAFLD ,improre the metabolism of blood glucose and lipid with few side-effects .It is effective and safe for atorvastatin in treating NAFLD patients .