血清25-羟维生素D与2型糖尿病足的关系

Association between Serum Vitamin D and Diabetic Foot Risk

目的：分析2型糖尿病患者25-羟维生素D水平与2型糖尿病患者糖尿病足发病的关系。方法：53例2型糖尿病患者,其中32例无糖尿病足（T2DM组）,21例为糖尿病足溃疡患者（DF组）。检测血清25羟维生素D水平及肝肾功能、空腹血糖、Hb A1c、血脂等。结果：DF组收缩压、空腹血糖、CRP、AST、LDL-C均高于T2DM组,而TG、TC、HDL-C水平低于T2DM组,差异有统计学意义（P〈0.05）。DF组血清维生素D水平显著低T2DM组（16.7±2.8 vs.29.2±10.9,P〈0.05）。Logistic回归分析显示,维生素D水平与糖尿病足发病相关（OR=2.32,CI：1.97-2.67,P〈0.05）。血维生素D四分位法分为四个水平,相较于最高水平,前三个四分位OR值分别为2.94（2.02-3.86）,2.49（2.02-2.96）,1.96（1.27-2.65）。结论：血25-羟维生素D水平降低是2型糖尿病患者发生糖尿病足的危险因素。

Objective： To investigate the association between serum vitamin D and the diabetic foot risk in type 2 diabetes patients. Method： This cross-sectional study enrolled 53 type 2 diabetes patients,21 of which were diabetic foot victims（ DFs） while the others were not（ T2DMs）. Clinical history and lab parameters,such as serum vitamin D,fasting blood glucose,Hb A1 c,serum lipids,kidney and liver function parameters were documented. Results： The SBG,FBG,CRP,LDH,uric acid,AST,LDL-C were significant higher,while the TG,TC,HDL-C was significant lower in DFs than in T2DMs（ P〈0. 05）. The DFs had significant lower serum vitamin D level than T2DMs（ 12. 7 vs. 27. 2,P〈0. 05. Logistic regression analysis showed that the vitamin D level was significantly associated with DF risk（ OR = 2. 32,CI： 1. 97 -2. 67,P〈0. 05）. While considering four quartile levels of vitamin D as categorical variable,the DF susceptibility is significantly correlated with decreasing vitamin D,with ORs as 1. 96（ 1. 27 - 2. 65）,2. 49（ 2. 02 - 2. 96）,2. 94（ 2. 02 -3. 86） comparing to the highest quartile level respectively. Conclusion： Decreasing serum vitamin D level is associated with higher DF risk in type 2 diabetes patients.