负压封闭引流技术治疗糖尿病足皮肤溃疡疗效的Meta分析

Vacuum sealing drainage in treatment of diabetic foot ulcer：a meta-analysis

目的：系统评价负压封闭引流技术（ vacuum sealing drainage，VSD）和常规换药方法对于治疗糖尿病足（ diabetic foot，DF）皮肤溃疡面的临床效果。方法计算机检索PubMed、CNKI和万方数据库，收集比较VSD与常规换药方法治疗DF溃疡的中、英文随机对照研究，检索时限为2000年1月至2014年1月发表的文章。选择符合要求的文献，采用RevMan5.2软件进行Meta分析。结果对符合纳入标准的7篇文献，646例患者进行Meta分析。结果显示对于DF溃疡，VSD治疗较常规换药治疗可缩短创面愈合时间、提高创面完全愈合率、缩短住院时间、减少住院费用、减少二次截肢率，2种方法比较差异有统计学意义（ P＜0.05）。结论 VSD治疗DF创面愈合时间、愈合率、住院时间、住院费用及二次截肢率等指标均优于常规换药方法。

Objective To evaluate clinical effects of vacuum sealing drainage （ VSD ） and conventional dressing in treatment of diabetic foot（DF）ulcers.Methods We searched PubMed, CNKI and WanFang data, and collected the Chinese and English randomized controlled studies on VSD and conventional dressing in treat-ment of DF ulcers.The retrieval time was from Jan.2000 to Jan.2014.RevMan5.2 software was used to make Meta-analysis.Results Seven papers including 646 cases met the standard and Meta analysis was conducted ac-cording to these data.The results showed that compared with conventional dressing, VSD treatment shortened the healing time, increased the complete healing rate, reduced hospital stay, and reduced hospital costs and seconda-ry amputation rates.The difference had statistical significance（P〈0.05）.Conclusion VSD is superior to con-ventional dressing method in terms of the healing time, healing rate, hospital stay, hospital costs and amputation rate.