同步放化疗联合微波热疗治疗局部晚期非小细胞肺癌的临床疗效

The Effect of Concurrent Radiochemotherapy Plus Microwave Thermotherapy on Locally Advanced Non-small Cell Lung Cancer

目的：评价同步放化疗联合微波热疗治疗局部晚期非小细胞肺癌（NSCLC）的近期疗效及不良反应情况。方法：将我院2012年9月-2014年9月就诊的局部晚期NSCLC患者60例,随机分为治疗组和对照组。治疗组予同步放化疗联合微波热疗治疗,对照组予同步放化疗治疗。评价两组患者在近期疗效、肺癌相关症状控制率及不良反应方面的差异。结果：近期疗效：治疗组86.7%,对照组60.0%,两组比较有显著差异（P〈0.05）。肺癌相关症状控制率：治疗组83.3%,对照组56.7%,两组比较有显著差异（P〈0.05）。不良反应：白细胞减少发生率治疗组Ⅰ～Ⅱ度为50.0%,Ⅲ～Ⅳ度为6.7%,对照组分别为63.3%和20.0%。放射性肺炎发生率治疗组Ⅰ～Ⅱ度为23.3%,Ⅲ～Ⅳ度为3.3%,对照组分别为40.0%和13.3%。放射性食管炎发生率治疗组Ⅰ～Ⅱ度为36.7%,Ⅲ～Ⅳ度为13.3%,对照组分别为53.3%和26.7%,上述三方面不良反应两组比较有显著差异（P〈0.05）。结论：同步放化疗联合热疗在近期疗效及肺癌相关症状控制方面均优于同步放化疗,并且治疗期间白细胞减少、放射性肺炎、放射性食管炎毒副反应均有所减轻。

Objective：To evaluate the recent curative effect and adverse reaction of concurrent radiochemotherapy plus microwave thermotherapy on locally advanced non-small cell lung cancer.Methods：60Patients with locally advanced non-small-cell lung cancer,who see a doctor in our hospital between September 2012 and September 2014,were randomly divided into the treatment group and the control group.The experiment group received concurrent radiochemotherapy plus Microwave thermotherapy,the control group concurrent radiochemotherapy only.Evaluating the differences of two groups in the recent curative effect,lung cancer related symptom control and adverse reaction.Results：The recent curative effect：the treatment group was 86.7%,control group 60.0%,comparing the two groups have significant difference（P〈0.05）.Lung cancer related symptoms control：the treatment group was 83.3%,control group56.7%,comparing the two groups have significant difference（P〈0.05）.Adverse reaction：the incidence of leukopenia in the treatment groupⅠ～Ⅱdegree was 50.0%,Ⅲ～Ⅳ degree 6.7%,the control group was 63.3% and 20.0% respectively.The incidence of radioactive pneumonia in the treatment groupⅠ ～ Ⅱdegree was 23.3%,Ⅲ ～ Ⅳ degree3.3%,the control group was 40.0%and 13.3%respectively.The incidence of Radioactive esophagitis in the treatment groupⅠ～Ⅱdegree was 36.7%,Ⅲ～Ⅳ degree 13.3%,the control group was 53.3% and 26.7%respectively.The above three Adverse reaction have significant difference comparing the two group（P〈0.05）.Conclusion：Concurrent radiochemotherapy plus microwave thermotherapy is superior to oncurrent chemoradiation in the recent curative effect and the Lung cancer related symptoms control.The incidence of leukopenia,radioactive pneumonia,radioactive esophagitis were alleviated During the treatment.