龙血竭胶囊联合替硝唑治疗宫颈炎的疗效分析及其对患者免疫球蛋白水平的影响研究

Curative efficacy of longxuejie capsule combinated with tinidazole in treatment of cervicitis and its effects on levels of immunoglobulin

目的探讨龙血竭胶囊联合替硝唑治疗慢性宫颈炎的疗效分析及对患者免疫球蛋白水平的影响。方法选取2013年1月~2014年6月间舟山市普陀区妇幼保健与计划生育服务中心收治的90例符合入选标准的慢性宫颈炎患者,使用分层随机法分为对照组（n=45）和观察组（n=45）。常规治疗基础上,对照组给予替硝唑治疗,观察组在对照组的基础上联合应用龙血竭胶囊治疗。观察比较2组患者临床疗效、症状积分及免疫球蛋白水平等情况。结果观察组的治疗总有效率为95.6%,显著高于对照组80.0%的总有效率（P〈0.05）。治疗后,与对照组相比,观察组分泌物、宫颈病变程度症状积分明显降低,免疫功能指标Ig G、IgM和IgA明显升高,均有统计学意义（P〈0.05）。对照组和观察组分别出现2例和3例下腹疼痛,未经治疗自行缓解。结论龙血竭胶囊联合替硝唑治疗慢性宫颈炎的疗效可靠,可以显著改善症状,提高机体免疫球蛋白水平。

Objective To investigate the clinical effect of longxuejie capsule in combination with tinidazole in the treatment of chronic cervicitis and its effects on levels of immunoglobulin.Methods 90 cases in our hospital from January 2013 to June 2014, with chronic cervicitis meeting the inclusion critera were randomly divided into 2 groups by method of stratified randomization equally.Control group （n=45） was treated with tinidazole and conventional treatments, while observation group （ n =45 ） was treated with tinidazole and longxuejie capsule.Then, the curative efficacy, scale of symptoms and levels of immunoglobulin were observed and compared.Results The therapeutic efficiency ratio of observation group was 95.6%, which was significantly higher than that of control group （ 80.0%, P〈0.05 ）.After the treatment, in comparison with the control group, scale of cervical secretion and severity of cervical lesion was statistically lower respectively than observation group （ P〈0.05 ）.As to immunological function, concentrations of IgG, IgM, IgA in observation group were statistically higher than that in control group after the treatment （P〈0.05）.The control group and observation group respectively in 2 cases and 3 cases of abdominal pain, alleviated by themselves without treatment.Conclusion longxuejie capsule combined with tinidazole is effective and reliable for patients with chronic cervicitis, which significantly improves symptoms and elevates levels of immunoglobulin.