血清孕酮、β-HCG联合检测在早期先兆流产中的诊断价值

Clinical value of serum progesterone,β-HCG joint detection in early threatened abortion

目的探讨血清孕酮、β-HCG联合检测在早期先兆流产中的临床价值。方法根据妊娠结果将本院收治的140例早期先兆流产患者分为2组,即先兆流产组(孕早期出现先兆流产症状,经过保胎治疗后顺利分娩者)90例和流产组(孕早期出现先兆流产症状,但经过保胎治疗后保胎失败,妊娠终止者)50例,并选取同期于本院进行孕期检查的90例正常孕妇作为对照组,分别检测3组患者的血清孕酮和β-HCG含量,并加以分析。结果 Western blot结果发现,流产组的血清孕酮值明显低于其他2组,流产组的β-HCG低于对照组和先兆流产组,差异具有统计学意义(P<0.05);先兆流产组与对照组之间的血清孕酮和β-HCG值差异无统计学意义。Western blot结果发现,流产组孕酮和β-HCG的表达低于对照组和先兆流产组,差异具有统计学意义(P<0.05)。血清孕酮值>12.2 ng/mL的产妇继续妊娠的机率大于自然流产,差异具有统计学意义(P<0.05);β-HCG>5000 IU/mL的产妇继续妊娠的机率大于自然流产,差异具有统计学意义(P<0.05)。对孕酮、β-HCG的单独检测及孕酮与β-HCG联合检测在妊娠结局中的特异性和敏感度的分析可知,2者联合检测的敏感度(87.09%)高于孕酮、β-HCG的单独检测(76.33%和60.34%)(均P<0.05)。孕酮、β-HCG的单独检测及孕酮与β-HCG联合检测的特异性分别为85.00%、100.00%和90.00%,其特异性差异不具有统计学意义。结论血清孕酮联合β-HCG检测对于早期先兆流产的诊断具有指导意义,可提高检测结果的准确性和敏感度,可有效指导临床。

Objective To investigate the clinical value of serum progesterone, β-HCG combined detection in early threatened abortion. Methods According to the result of pregnancy in the hospital, 140 cases of early threatened abortion maternal and were divided into two groups, that threatened abortion group 90 cases（ threatened abortion symptoms in early pregnancy but after follow-up miscarriage treatment successful producers）.And abortion 50 cases （threatened abortion symptoms in early pregnancy, but after conventional therapy, the miscarriage was failure and termination of pregnancy ）.And 90 cases of normal pregnant women were selected as control group in the same period of birth to check in the hospital,and detected in serum progesterone and β-HCG content of three groups of patients, and analyzed.Results Between threatened abortion group and the control group, serum progesterone and β-HCG was no significant difference.West blot results, the value of serum progesterone in abortion group was significantly lower than the other 2 groups, abortion group β-HCG was lower than that of the control group and threatened abortion group, with significant difference （ P〈0.05）.When serum progesterone values 〉12.2ng/mL, maternal pregnancy continued probability was greater than the natural abortion, with significant difference （ P〈0.05 ）.β-HCG 〉5000 IU/mL, maternal pregnancy continued probability was greater than the natural abortion, with significant difference （ P〈0.05 ）.Progesterone, β-HCG, progesterone and β-HCG joint detection, joint detection sensitivity （ 87.09%） was higher than progesterone, β-HCG alone detection （ 76.33% and 60.34%） , the difference was statistically significant （P〈0.05 ）.Progesterone, β-HCG, progesterone joint detection of specific were 85.00%, 100.00% and 90.00%, there were not statistically significant.Conclusions Serum progesterone and β-HCG joint detection for early threatened abortion diagnosis has guiding significance, can improve the accuracy and sensitivity of the test results, which can effectively guide clinical practice.