人参多糖辅助GP化疗方案治疗非小细胞肺癌的有效性和安全性研究

Study on the effectiveness and safety of ginseng polysaccharide adjuvant GP chemotherapy in the treatment of non small cell lung cancer

目的探讨人参多糖注射液辅助GP化疗方案治疗非小细胞肺癌的疗效。方法选择2011年6月~2013年6月收治的非小细胞肺癌患者130例,随机分为2组,每组65例。对照组给予吉西他滨和顺铂（GP方案）进行治疗,观察组在GP方案的基础上加用人参多糖注射液。连续治疗3个月后,对2组患者的治疗效果、T淋巴细胞亚群、不良反应、生存质量评分进行比较,随访1年后对2组患者的生存率进行比较。结果观察组的总有效率为58.5%,显著优于对照组（41.5%）,差异具有统计学意义（χ^2=3.72,P〈0.05）;观察组的CD3、CD4和CD4/CD8均显著高于对照组,差异具有统计学意义（t=5.735、7.885、7.326,均P〈0.05）,而CD8显著低于对照组,差异具有统计学意义（t=2.442,P〈0.05）;治疗过程中2组患者的主要不良反应为骨髓抑制（表现为白细胞下降、血小板下降和贫血等症状）和胃肠道反应;治疗后观察组的生存质量评分为（71.5±12.9）,显著高于对照组（64.2±12.2）,差异具有统计学意义（t=3.315,P〈0.05）;观察组的1年生存率为63.1%,对照组为52.3%,无显著差异。结论在GP化疗方案的基础上加用人参多糖注射液治疗非小细胞肺癌临床效果显著,免疫力显著增强,副作用风险降低,生存质量好。

Objective To discuss the treatment effect of ginseng polysaccharide injection auxiliary GP chemotherapy for patients with non-small cell lung cancer.Methods 130 cases of patients with non-small cell lung cancer from June 2011 to June 2013 were randomly divided into two groups, 65 cases in each group.The control group was given gemcitabine and cisplatin treatment.The observation group were treated with ginseng polysaccharide injection on the basis of the control group.After 3 months of continuous therapy, the therapeutic effect, T-lymphocyte subsets, adverse events, quality of life scores of the two groups were compared, and survival in two groups of patients were also compared after 1 year follow-up.Results The total efficiency and clinical benefit rate in observation group were 58.5%, significantly better than the control group （ 41.5%） , the difference was statistically significant （χ^2 =3.72, P〈0.05）;CD3, CD4 and CD4 /CD8 in observation group were significantly higher than the control group, the differences were statistically significant （t =5.735, 7.885, 7.326, P〈0.05）, whereas CD8 was significantly lower than the control group, the difference was statistically significant （t=2.442, P〈0.05）.The main adverse reactions of the two groups of patients during treatment were myelosuppression （WBC and platelet decreasing and anemia ） and gastrointestinal reaction.Score of life quality in observation group was （ 71.5 ±12.9 ） after treatment, significantly higher than the control group （64.2 ±12.2）, the difference was statistically significant （t=3.315, P〈0.05）.1-year survival rate in the observation group were 63.1%, and 52.3% in the control group.Conclusion Ginseng Polysaccharide injection auxiliary GP chemotherapy for non-small cell lung cancer has significantly efficacy, enhances immunity, reduces side effects, better quality of life.