酒依赖与双相障碍共病患者的特征及生活质量综合研究

Comprehensive study on the characteristics and quality of life of patients with comorbid alcohol dependence and bipolar disorder

目的探究酒依赖与双相障碍共病(comorbid alcohol dependence and bipolar disorder,CADBD)患者的特征以及了解其生活质量。方法选择2010年10月-2014年5月在浙江萧山医院接受治疗的60例CADBD患者作为本次研究的观察组,以及同期检查正常的健康体检者60例作为对照组。分别应用躁狂自评量表(BRMS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)以及人格障碍临床诊断(SCID-Ⅱ)对观察组和对照组进行特征评定。并采用生活质量综合评定量表(GQOLI-74)对观察组和对照组进行生活质量对比评价。结果观察组患者的BRMS、SAS、SDS、SCID-Ⅱ评分值明显高于对照组,且差异有统计学意义(P<0.05);观察组患者的GQOLI-74生活质量综合评分值明显低于对照组,且差异有统计学意义(P<0.05)。结论 CADBD患者的负性情感,如躁狂、抑郁、焦虑、人格障碍等表现突出,且其生活质量明显降低,该表征对CADBD患者的诊断具有重要的诊断价值。

Objective To explore the characteristics of patients with comorbid alcohol dependence and bipolar disorder （CAD- BD） and to investigate their quality of life. Methods Sixty patients with CADBD accepted treatment in Xiaoshan Hospital from October 2010 to May 2014 were selected as the observation group in this study, while 60 healthy check - up people were si- multaneously selected as the control group. Bech- Rafaelsen Mania Rating Scale （BRMS）, Self- rating Anxiety Scale （SAS）, Self- rating Depression Scale （SDS） and the Structured Clinical Interview for DSM - II （SCID - II） were used to a～eas the characteristics of the observation group and the control group. And then Generic Quality of Life Inventory - 74 （GQOLI - 74） was employed to evaluate the quality of life in the two groups. Results The scores of BRMS, SAS, SDS and SCID- lI in the observation groups were significantly higher than those in the control group, with statistically significant differences （P 〈 0.05）. The scores of GQOLI- 74 in the observation groups were significantly lower than those in the control group, and the differences were statistically significant （P 〈 0.05）. Conclusions Patients with CADBD have obvious negative emotiorus, such as mania, depression, anxiety and personality disorder, and their quality of life is significantly decreased. The above - mentioned characteristics have an important diagnostic value in CADBD.