摘要
微小RNA（miRNAs）是一类具有调控功能的内源性非编码单链小分子RNA，长约18-24个核苷酸，与鼻咽癌（nasopharyngeal carcinoma，NPC）的发生发展、诊断以及预后、转归有关。BamHlA右向转录（BamHl A rightward transcripts，BARTs）是EB病毒（EBV）中一组经转录后选择性多剪接的基因产物，存在于EBV所有潜伏状态的miRNA，共22种（miR-BARTl-22），并表达于NPC等EBV感染相关的恶性肿瘤。阐明miR-BARTs在NPC的作用机制对指导临床治疗有重要意义。
MicroRNAs(miRNAs)are a class of endogenous small non-coding single-stranded 18-24 nucleotide RNAs that play important roles in gene regulation.It has been reported that miRNAs play a vital role in the occurrence,development,diagnosis and prognosis of nasopharyn-geal carcinoma(NPC).BamH1-A rightward transcripts(BARTs),including 22 viral miRNAs,are located in long alternative spliced Epstein-Barr virus(EBV)transcripts and expressed in EBV-as-sociated malignant tumors.It is of great clinical significance to illuminate the mechanism of action of miR-BARTs in NPC.
出处
《实用临床医学（江西）》
CAS
2015年第5期96-98,107,共4页
Practical Clinical Medicine
关键词
鼻咽癌
BamH1A
右向转录
EB病毒
基因调控
nasopharyngeal carcinoma
BamH1A
rightward transcript
EB virus
gene regulation
