摘要
目的:研究老鼠簕叶的化学成分。方法:采用硅胶和凝胶柱色谱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。采用检测流感病毒神经氨酸酶活性测定所分离得到化合物的抗流感病毒活性。结果:从老鼠簕叶中分离得到5个化合物,分别鉴定为:blepharin(1)、麦角甾苷(2)、异类叶升麻苷(3)、胡萝卜苷(4)、豆甾醇-3-O-β-D-葡萄糖苷(5)。结论:以上化合物均为首次从该植物叶中分离得到,化合物1-3具有一定的抗流感病毒活性。
Objective:To study the chemical constituents from the leaves of Acanthus ilicifolius. Methods :The compounds were isolated by silica and gel column chromatographic methods and identified by spectroscopic analysis. The anti-influenza virus activities of these compounds were obtained by measuring the neuraminidase activity of influenza virus. Results:Five compounds were isolated and their structures were identified as blepharin( 1 ) , acteoside (2) , isoverbascoside ( 3 ), daucosterol ( 4 ), and 3-O-β-D-glucopyranosyl-stig- masterol(5 ). Conclusion :All the compounds are isolated from the leaves of Acanthus ilicifolius for the first time, and compounds 1 -3 exhibit the anti-influenza virus activities.
出处
《中药材》
CAS
CSCD
北大核心
2015年第3期527-530,共4页
Journal of Chinese Medicinal Materials
基金
深圳市海洋药物工程中心基金(深发改【2011】1673号)
关键词
老鼠簕
化学成分
苯乙醇苷
抗流感病毒
Acanthus ilicifolius L.
Chemical constituents
Phenylethanoid glycosides
Anti-influenza virus