摘要
目的:观察头孢唑林联合肝素封管在预防血液透析导管相关性感染的疗效。方法:将2010年1月至2014年5月使用长期透析导管进行维持性血液透析的终末期肾病患者42例随机分为观察组和对照组各21例,观察组使用头孢唑林(50 mg/ml)加肝素生理盐水(3000 u/ml)封管,对照组仅使用肝素生理盐水(3000 u/ml)封管,连续观察6个月,比较两组导管相关性感染的发生情况。结果 :两组患者均未出现导管出口感染及皮下隧道感染。观察组无1例发生导管相关血流感染(CRBSI),对照组出现6例次导管相关性菌血症,两组长期导管感染发生率有显著差异(P<0.05)。结论:与单纯肝素封管相比,头孢唑林联合肝素封管可显著降低导管相关性血流感染发生率。
Objective： To investigate curative effect of preventing tunneled catheter-related infections by using Cefazolin-Heparin locking solutions in hemodialysis. Methods： From January 2010 to May 2014, 42 cases underwent hemodialysis were randomly divided into research group （n=21） and control group （n=21）. Cefazolin （50 mg/ml） combined with Heparin（3000 u/ml）and just Heparin（3000 u/ml）solution was filled in catheter lumens at the end of each hemodialysis session in treatment group and control group respectively. Incidence of infections about the two groups was compared after a continuous observation for 6 months. Results： Exit site or tunnel infection was not occurred in each group but 6 patients developed catheter-related bloodstream infection （CRBSI） in control group. There was no CRBSI occurred in treatment group and the different incidence of CRBSI between the two groups was significant（P〈0.05）. Conclusion： Comparing with Heparin solution only of catheter-restricted filling, Cefazolin and Heparin may significantly reduce the incidence of catheter-related bloodstream infection in hemodialysis.
出处
《岭南急诊医学杂志》
2015年第2期110-111,114,共3页
Lingnan Journal of Emergency Medicine
