血清和肽素、降钙素原对脑出血合并肺部感染早期诊断及判断预后的价值

The value of detection of copeptin and procalcitonin in early diagnosis and prognosis of cerebral hemorrhage-associated pulmonary infection

目的研究血清和肽素、降钙素原(PCT)与脑出血合并肺部感染患者早期诊断及预后之间的关系。方法选取该院2012年1月至2013年12月诊断为脑出血、脑出血合并肺部感染患者共120例及同期体检的健康者60例(对照组),比较3组血清和肽素与PCT水平的差异。结果脑出血合并肺部感染组和肽素、PCT水平均高于脑出血组和对照组,差异有统计学意义(P<0.05)。脑出血合并肺部感染生存组血清和肽素、PCT、C反应蛋白(CRP)水平及急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分均明显低于死亡组,差异有统计学意义(P<0.05)。结论血清和肽素、PCT和脑出血合并肺部感染关系密切,对脑出血合并肺部感染患者早期诊断及预后具有重要临床价值。

Objective To investigate that the relationship of serum concentration of copeptin ,procalcitonin（PCT ）and early diagnosis ,prognosis in patients with cerebral hemorrhage‐associated pulmonary infection .Methods One hundred and twenty pa‐tients with acute cerebral hemorrhage ,acute cerebral hemorrhage‐associated pulmonary infection and 60 healthy individuals （the control group） admitted in our hospital from January 2012 to December 2013 were selected and detected for serum copeptin and procalcitonin .The differences of serum copeptin ,procalcitonin levels were compared in controls ,in patients with cerebral hemor‐rhage and cerebral hemorrhage‐associated pulmonary infection and their correlation was analyzed .Results The levels of serum copeptin in the cerebral hemorrhage‐associated pulmonary infection were significantly higher than that in control group and the cer‐ebral hemorrhage （P〈0 .05） .The levels of serum procalcitonin in control group and the cerebral hemorrhage were significantly lower than that in the cerebral hemorrhage‐associated pulmonary infection ,the levels of serum C‐reactive protein ,copeptin ,procalci‐tonin and the APACHEⅡ scores of the patients with survival group were significantly lower than those with non‐survival group （P〈0 .05） .Conclusion The levels of serum copeptin and procalcitonin are correlated intimately with cerebral hemorrhage‐associat‐ed pulmonary infection .They are important clinical parameters to reflect the early diagnosis and prognosis of cerebral hemorrhage‐associated pulmonary infection .