辅助生殖技术对子代儿童患恶性肿瘤风险的Meta分析

A Meta analysis of the cancer incidence of children conceived by assisted reproductive technology

目的评价辅助生殖技术(ART)对子代儿童恶性肿瘤发生率的影响。方法通过计算机检索EBSCO全文数据库、Pubmed、德国Springer期刊数据库、Cochrane Libarary、中国学术期刊网络出版总库期(CNKI)、万方和维普中文期刊全文数据库等,并辅助其他检索方式,纳入ART术后妊娠和自然妊娠的儿童健康状况的队列研究,使用RevMan5.0软件进行Meta分析。结果研究共纳入符合标准文献16篇,共89 894例ART出生子代。Meta分析结果显示,ART与非ART出生子代恶性肿瘤发生率之间差异无统计学意义(OR=1.85,P>0.05)。结论 ART子代罹患恶性肿瘤的概率与非ART基本一致,但其远期的潜在风险尚未明确。

Objective To evaluate the incidence of cancer in children born with assisted reproductive technology （ART ） . Methods The literatures were obtained by computer through EBSCO full‐text database ,Pubmed ,Germany Springer journal data‐base ,Cochrane Libarary ,Chinese academic journals published in the pool of network （CNKI） ,Wanfang and Veipu Chinese Journal Full‐text databases ,and other search methods .ART and child health natural pregnancy cohort study were included .The Meta‐anal‐ysis was conducted by using RevMan5 .0 software .Results Sixteen studies were included according to the criteria ,and 89 894 cases of ART‐born offspring were collected .The results of Meta analysis revealed that there was no significant difference between ART and non‐ART children on the incidence of tumor （OR= 1 .85 ,P〉0 .05） .Conclusion This study showed that the probability of ART offspring suffering from malignant is basically the same with non‐ART children ,but the potential long‐term risks are not yet clear .