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冠心病患者血清卵泡抑素样蛋白-1水平变化及临床意义 被引量:5

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摘要 目的观察冠心病患者血清卵泡抑素样蛋白1(FSTL-1)水平变化,探讨其临床意义。方法冠心病患者184例(冠心病组),按不同类型分为稳定型心绞痛组(SAP组,n=72)、不稳定型心绞痛组(UAP组,n=59)、急性心肌梗死组(AMI组,n=53);同期行冠脉造影阴性患者62例为对照组(n=62)。采用ELISA法测定4组血清FSTL-1水平。结果冠心病组FSTL-1明显高于对照组(P<0.05);AMI组、UAP组FSTL-1明显高于SAP组及对照组(P<0.05);SAP组FSTL-1与对照组比较,差异无统计学意义(P>0.05)。UAP组FSTL-1与AMI组比较,差异无统计学意义(P>0.05)。结论冠心病患者FSTL-1明显升高,FSTL-1可能与冠状动脉斑块稳定性有一定关系。
出处 《河北医药》 CAS 2015年第11期1711-1712,共2页 Hebei Medical Journal
基金 陕西省教育厅基金项目(编号:12JK0766)
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参考文献10

  • 1Hambroek HO, Kaufmann B, Muller S, el al. Structural characterization of TSC-36/Flik : analysis of two charge isoforms. J Biol Chem, 2004,279 : 11727-11735.
  • 2Ehara Y, Sakurai D, Tsuchiya N, et al. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms arenot associated with genetic susceptibility. Clin Exp Rheumatol, 2004,22 : 707 -712.
  • 3Sreekanth PR, Ramona B, Katyayni V, et al. Novel Glioblastoma Markers with Diagnostic and Prognostic Value Identified through Transcriptome A- nalysis. Clin Cancer Res,2008,14:2978-2987.
  • 4Oshima Y, Ouchi N, Sato K, et al. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation, 2008, 117:3099-3108.
  • 5Takehara-Kasamatsu Y, Tsuchida K, Nakatani M, et al. Characterization of follistatin related gene as a negative regulatory factor for activin family members during mouse heart development. J Med Invest,2007,54:276- 288.
  • 6徐艳,程晓曙.卵泡抑素样蛋白与心血管疾病[J].中华心血管病杂志,2011,39(10):973-976. 被引量:4
  • 7Ouchi N, Oshima Y, Ohashi K, et al. Follistatin-likel, a secreted muscle protein,promotes endothelial cell functionand revascularization in ische- mic tissue through a nitric-oxide synthase-dependent mechanism. J Biol Chem,2008 ;283 : 32802-32811.
  • 8Ogura Y, Ouchi N, Ohashi K, et al. Therapeutic impact offollistatin-like f on myocardial ischemic injury in preclinical models. Circulation,2012, 126 : 1728-1738.
  • 9Widera C, Horn-Wichmann R, Kempf T, t aL Circulating concentrations of follistatin-like 1 in healthy individuals and patients with acute coronary syndrome as assessed by an immunoluminometric sandwich assay. Clin Chem 12009,55 : 1794-1800.
  • 10Widera C, Giannitsis E, Kempf T, et al. Identification of fol-listatin-like 1 by expression cloning as an activator of thegrowth differentiation factor 15 gene and a prognostic biomarker in acute coronary syndrome. Clin Chem,2012,58 : 1233-1241.

二级参考文献41

  • 1Shibanuma M,Mashimo J,Mita A,et al.Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes,one of which seems to encode a follistatin-related polypeptide.Eur J Biochem,1993,217:13-19.
  • 2Hambrock HO,Kaufmann B,Müller S,et al.Structural characterization of TSC-36/Flik:analysis of two charge isoforms.J Biol Chem,2004,279:11727-11735.
  • 3Hayette S,Gadoux M,Martel S,et al.FLRG (follistatin-related gene),a new target of chromosomal rearrangement in malignant blood disorders.Oncogene,1998,16:2949-2954.
  • 4Sugino H,Sugino K,Hashimoto O,et al.Follistatin and its role as an activin-binding protein.J Med Invest,1997 (1-2),44:1-14.
  • 5Schneyer AL,Wang QF,Sidis Y,et al.Differential distribution of follistatin isoforms:application of a new FS315-specific immunoassay.J Clin Endocrinol Metab,2004,89:5067-5075.
  • 6Welt C,Sidis Y,Keutmann H,et al.Activins,inhibins,and follistatins:from endocrinology to signaling.A paradigm for the new millennium.Exp Biol Med (Maywood),2002,227:724-752.
  • 7Sidis Y,Tortoriello DV,Holmes WE,et al.Follistatin-related protein and follistatin differentially neutralize endogenous vs.exogenous activin.Endocrinology,2002,143:1613-1624.
  • 8Adams D,Larman B,Oxburgh L.Developmental expression of mouse Follistatin-like 1 (Fstl1):dynamic regulation during organogenesis of the kidney and lung.Gene Expr Patterns,2007,7:491-500.
  • 9Towers P,Patel K,Withington S,et al.Flik,a chick follistatinrelated gene,functions in gastrular dorsalisation/neural induction and in subsequent maintenance of midline Sonic hedgehog signalling.Dev Biol,1999,214:298-317.
  • 10Okabayashi K,Shoji H,Onuma Y,et al.cDNA cloning and distribution of the Xenopus follistatin-related protein.Biochem Biophys Res Commun,1999,254:42-48.

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同被引文献58

  • 1李娇,李新明,柳亮,王温慧,丛欣鹏,侯士强.血清HMGB1和hs-CRP水平与冠心病严重程度的相关性分析[J].中国动脉硬化杂志,2015,23(2):175-179. 被引量:17
  • 2刘晨梅,蔡忠,郭杰,郑翠英,王庆彤,艾静,张连祥.心肌标志物对急性心肌梗死诊断价值分析[J].河北医药,2004,26(7):559-560. 被引量:3
  • 3陈树宝,李万镇,马沛然,钱永如,宁寿葆.小儿心力衰竭诊断与治疗建议[J].中华儿科杂志,2006,44(10):753-757. 被引量:111
  • 4Bhatt H,Safford M,Glasser S.Coronary heart disease risk factors and outcomes in the twenty-first century:findings from the REasons for Geographic and Racial Differences in Stroke(REGARDS)Study[J].Curr Hypertens Rep,2015,17(4):541.
  • 5Tofield A.Heart disease and stroke decline in Europe[J].Eur Heart J,2014,35(42):2930.
  • 6Mozaffarian D,Benjamin EJ,Go AS,et al.Executive Summary:Heart Disease and Stroke Statistics-2016Update:A Report From the American Heart Association[J].Circulation,2016,133(4):447-454.
  • 7Zhou M,Wang H,Zhu J,et al.Cause-specific mortality for240 causes in China during 1990-2013:a systematic subnational analysis for the Global Burden of Disease Study2013[J].Lancet,2016,387(10015):251-272.
  • 8Top 10cardiovascular advances of 2014.Highlights include promising new medications,devices,and procedures to prevent and treat heart disease and stroke[J].Harv Heart Lett,2014,25(4):1,7.
  • 9Kawabata D,Tanaka M,Fujii T,et al.Ameliorative effects of follistatin-related protein/TSC-36/FSTL1 on joint inflammation in a mouse model of arthritis[J].Arthritis Rheum,2004,50(2):660-668.
  • 10Adams D,Larman B,Oxburgh L.Developmental expression of mouse Follistatin-like 1(Fstl1):Dynamic regulation during organogenesis of the kidney and lung[J].Gene Expr Patterns,2007,7(4):491-500.

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