精神分裂症高危人群和首次发病未用药患者及正常人群大脑结构比较

Brain morphology of population at high risk of and patients with schizophrenia

目的:比较精神分裂症患者一级亲属(高危人群)和家族史阴性、首发未用药患者及正常人群之间大脑结构形态的差异。方法:应用基于体素的形态学研究方法(VBM),对满足入组标准的高危组(患者的一级亲属且无精神症状)10例、首发组(首次发病未用药且家族史阴性)10例及正常人群(正常对照组)10名进行头颅核磁共振扫描和VBM分析,比较各组之间各脑区灰质体积的变化。结果:与正常对照组相比,高危组左侧扣带回内部和扣带旁回的灰质体积出现显著性缺损(cluster=26voxel;MNI:-7,-27,30);首发组左侧丘脑灰质体积较小(cluster=580 voxel;MNI:-10,-17,12)。与高危组相比,首发组左侧岛叶灰质体积较小(cluster=1 197 voxel;MNI:-38,-16,-5)。结论:精神分裂症患者大脑结构异常与遗传和环境均有一定的联系。

Objective：By voxel based morphometry（ VBM）to compare brain morphological difference between first degree relatives of schizophrenic patients（ high-risk group）and negative family history,first-epi-sode,drug-nave patients in schizophrenia and healthy controls. Method：We performed magnetic resonance scanning scans on those meeting the entry criteria for high-risk group（n=10）,the first-episode group（n=10） and the normal group（ n=10 ）,then compared gray matter volume between the groups by VBM. Resuits：Compared with the healthy controls,high-risk group showed significant gray matter volume reduction of the left median cingulate and paracingulate gyri（cluster=26 voxel：MNI：-7,-27,30）. Smaller gray matter volume in the left side of the thalamus（cluster=580 voxel：MNI：-10,-17,12）was found in the first-episode group. Compared to high-risk group,first-episode group demonstrated significant gray matter volume reduction of the left insula（cluster=1 197 voxel;MNI：-38,-16,-5）. Conciusion：Brain structural abnormalities of schizophrenic patients may be associated with both heredity and environment.