雌激素及雄激素受体基因与复发性自然流产之间关联性的研究进展

The estrogen and androgen receptor gene in the progression of recurrent spontaneous abortion

RSA是妊娠常见的并发症之一。RSA病因极其复杂,尽管已经提出了一些可能的机制,临床上排除了遗传因素、内分泌因素、感染性因素、解剖学因素、自身抗体因素外,仍有大约50%的患者病因未明。激素因素已经被提出可能与RSA有关。激素分泌紊乱,可能会导致某些内分泌腺体,如垂体,甲状腺,肾上腺,以及卵巢发生异常。研究发现雌激素受体及雄激素受体基因与RSA的发生有关联性。本文就雌激素及雄激素受体基因与RSA之间关联性的研究进展进行综述。

Epidemiological studies have suggested that recurrent spontaneous abortion （RSA） comprise a multifactorial condition enhanced by a variety of genetic and environmental factors. Some known etiologic factors of RSAs include parental chromosome abnormalities, endocrinologic diseases, infections, immunologic factors, nutritional, and environmental factors. However, the true cause of RSA cannot be determined in approximately 50%of cases. Hormonal factors have been proposed to contribute to RSA. Hormonal disorders may result from problems with certain endocrine glands, such as the pituitary, thyroid, adrenal, as well as the ovaries. Previous studies have reported the variations of estrogen and androgen receptor gene to be associated with RSA.