纯胶与β-环糊精2种包合材料的比较

Comparative Study of Two Kinds of Inclusion Materials on Purity Gum and β-Cyclodextrin

目的:比较纯胶与β-环糊精(β-cyclodextrin,β-CD)的包合效果。方法:以包合率与包合物收率为指标,选取纯胶与β-CD为包合材料,采用高压均质机、磁力搅拌器、超声波细胞破碎仪、超声波清洗器4种方法分别对羌活、连翘、辛夷挥发油进行包合,通过单因素试验优选包合工艺,包合物进行差示扫描量热分析与红外光谱表征。结果:纯胶的包合率明显高于β-CD,包合物收率略低于β-CD。挥发油已被纯胶包合,红外谱图中纯胶包合物的最大吸收峰相对于纯胶有向高频数迁移,表明纯胶包合物为一新生物相,且包合效果稳定。结论:以纯胶为包合材料,采用磁力搅拌法制备包合物的工艺简单且包合效果好。

Objective： A comparative study on inclusion effect of purity gum and β-cyclodextrin（ β-CD）. Method： With inclusion rate of volatile oil and yield of inclusion complex as indexes,purity gum and β-CD as inclusion materials,four kinds of inclusion technique were adopted to inclusion of volatile oil from Notopterygii Rhizoma et Radix,Forsythiae Fructus and Magnoliae Flos,inclusion process was optimized by single factor test,differential scanning calorimetry（ DSC） and infrared spectrum was used to characterize technology of inclusion complex. Result： Inclusion rate of purity gum was significantly higher than β-CD, but recovery of inclusion complex of purity gum was slightly lower than β-CD. DSC diagram of purity gum inclusion curve did not appear characteristic peaks of volatile oil showed that oil has been involved. Maximum absorption peak of purity gum inclusion in infrared spectrum graph with respecting to purity gum have migrated to high frequency, it showed purity gum inclusion was a new biological phase,and inclusion effect was stable. Conclusion： Taking purity gum as inclusion material, magnetic stirring method for inclusion technique to prepare inclusion complex, not only process is simple,and has good effect of inclusion.