荷叶、绞股蓝及紫苏叶提取物复方制剂的减肥降脂作用

Effects of Extract Compound Preparation of Nelumbinis Folium, Herba seu Radix Gynostemmatis Pentaphylli and Perillae Folium on Reducing of Body Weight and Serum Lipid

目的:探讨荷叶、绞股蓝及紫苏叶提取物制成复方制剂的预防性减肥降脂作用。方法:选用SD雄性大鼠为研究对象,高脂饲料喂养,建立肥胖高血脂大鼠模型,将荷叶提取物、绞股蓝提取物、紫苏叶提取物制成复方制剂并进行减肥降脂试验。大鼠随机分为正常组、模型组及复方制剂高、中、低剂量组,检测各组大鼠的体重、血脂指标(总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白)、脂肪质量、脂/体比及Lee's指数。结果:3个复方制剂组较模型组体重增长缓慢且有显著性变化;3个复方制剂组体内脂肪质量较模型组小且有显著性变化;3个复方制剂组血清总胆固醇、甘油三酯含量较模型组少且差异显著;3个复方制剂组的高密度脂蛋白胆固醇均显著高于模型组,低密度脂蛋白则均显著低于模型组;3个复方制剂组Lee's指数较模型组有显著性变化。结论:复方制剂不同剂量均对肥胖症、高血脂症具有良好的预防和治疗的作用。

Objective： To discuss effect of extract compound preparation of Nelumbinis Folium,Herba seu Radix Gynostemmatis Pentaphylli and Perillae Folium on reducing of body weight and secrum lipid. Method：Male SD rats were randomly divided into 5 groups according to body weight, including the normal group, the model group,extract compound preparation in low,middle and high dosage groups. Rat body weight, serum lipids,fat mass and ratio of fat mass and body weight were investigated. Result： Compared with the model group,rat body weight of three extract compound preparation groups increased slowly with a significant change; fat mass was smaller with a significant change; total cholesterol（ TC）,serum truglyceride（ TG）,low density lipoproteincholesterol（ LDL-C） were significantly decreased in three experimental groups; Lee＇s index of three experimental groups had a significant change; high density lipoprotein-cholesterol（ HDL-C） of three experimental groups were higher than the model group. Conclusion： This extract compound preparation has a good anti-obesity antihyperlipemia effectiveness.