厚朴温中汤加味配伍吗丁啉对功能性消化不良血浆胃肠激素的影响

Impact of Houpu Wenzhong Decoction Combined with Domperidone on Plasma Gastrointestinal Hormone and Treatment Effect for Functional Dyspepsia

目的:探讨厚朴温中汤加味配伍吗丁啉对功能性消化不良血浆胃动素及治疗效果的影响。方法:选择115例功能性消化不良患者为研究对象,采用随机数字表法分为观察组58例及对照组57例,对照组给予吗丁啉口服治疗,观察组在对照组基础上联合厚朴温中汤加味配伍口服治疗,两组疗程均为3周,观察两组患者治疗临床疗效、临床症状评分、两组治疗前后血浆胃肠激素水平及药物不良反应。结果:观察组治疗有效率明显高于对照组(94.83%VS 80.70%);观察组腹胀感、早饱感、上腹痛及上腹灼烧感等症状评分临床症状积分均明显低于对照组;观察组血浆胃动素水平明显高于对照组(279.31±60.47)VS(224.54±57.62)ng·L-1,血浆生长抑素水平明显低于对照组(9.38±4.14)VS(12.53±3.79)ng·L-1;两组均无明显药物不良反应发生。结论:厚朴温中汤加味配伍吗丁啉有助于改善血浆胃动素及生长抑素水平,缓解临床症状,提高临床疗效,是一种安全有效的中西药结合治疗方案。

Objective： The aim of this article was to study the effect of Houpu Wenzhong decoction combined with domperidone on plasma gastrointestinal hormone and curative effect on functional dyspepsia.Method： One hundred and fifteen cases with functional dyspepsia were divided into observation group（ 58 cases）and control group（ 57 cases）, with control group given domperidone and observation group treated with domperidone and Houpu Wenzhong decoction. Efficacy,clinical symptoms scores,plasma gastrointestinal hormone level,and adverse drug reactions were compared between two groups. Result： Curative efficacy in observation group was significantly higher than that in control group（ 94. 83% VS 80. 70%）; clinical symptom scores were all significantly lower than those in control group; in observation group,plasma motilin level was significantly higher than in control group [（ 279. 31 ± 60. 47） VS（ 224. 54 ± 57. 62） ng·L- 1],and the plasma somatostatin in observation group was significantly lower than in control group [（ 9. 38 ± 4. 14） VS（ 12. 53 ± 3. 79） ng·L- 1];there was no obvious adverse drug reactions occurred in both two groups. Conclusion： Houpu Wenzhong decoction combined with domperidone can help to improve plasma motilin and somatostatin levels,relieve the clinical symptoms,and improve the clinical curative effect.