右美托咪定对颅脑损伤患者血清S100β蛋白及神经元特异烯醇化酶的影响

Effect of dexmedetomidine on serum S100β protein and neuron specific enolase among patients with traumatic brain injury

目的探讨在全身麻醉下使用右美托咪定对颅脑损伤患者血清S100β蛋白及神经元特异性烯醇化酶(NSE)水平的影响。方法 80例在全身麻醉下行开颅血肿清除去骨瓣减压术患者,随机分为右美托咪定组(观察组,=40)和0.9%氯化钠注射液组(对照组,=40)分别于麻醉诱导即刻(T1)、术毕即刻(T2)、术毕6h(T3)、术毕12 h(T4)、术毕24 h(T5)抽取患者静脉血,用酶联免疫吸附(ELISA)测定S100β蛋白及NSE值。结果两组血清S100β蛋白、NSE浓度T2、T3、T4及T5较T1均显著升高(均<0.05);与对照组比较,观察组T2、T3、T4及T5时点的S100蛋白、NSE浓度均明显降低,差异均有统计学意义(均<0.05)。结论使用右美托咪定可使颅脑损伤患者血清S100蛋白及NSE浓度下降,具有脑保护作用。

Objective To investigate the effects of dexmedetomidine on S100β albumen and neuron specific enolase （NSE） of patients undergoing clearance ofhematoma by craniotomy with bone flap. Methods A total of 80 patients receiving clearance ofhematoma by craniotomy with bone flap were randomly divided into the control group（normal saline） and the study group （dcxmedctomidine group）with 40 cases in each group. The venous blood was drawn before anesthesia induction, at the end of surgery, six hours after operation, 12 hours after operation, and 24 hours after operation.The serum S100β and NSE were determined respectively by Enzyme-Linked lmmuno Sorbent Assay（ELISA）.Results The serum S100β and NSE of the study group were significantly lower than those of the control group, at the end of surgery, six hours after operation, 12 hours after operation, and 24 hours after operation（P 〈 0.05）. Conclusions Dexmedetomidine can reduce the serum levels of S 10013 and NSE among the patients undergoing clearance ofhematoma by craniotomy with bone flap during perioperative period, thus it takes effect on the protection of the brain for the patients with craniocerebral injury.