140株嗜麦芽窄食单胞菌的临床分布及耐药性分析

Analysis of clinical distribution and drug resistance of 140 Stennotrophomonas maltophilia strains

目的研究嗜麦芽窄食单胞菌的临床分布和耐药特点,为临床预防和治疗嗜麦芽窄食单胞菌感染及医院感染控制提供依据。方法采用微生物鉴定仪对2011至2014年分离到的140株嗜麦芽窄食单胞菌进行培养鉴定和药物敏感试验,并做临床常用抗生素耐药性分析,应用WHONET5.5软件对数据进行统计学分析。结果 140株嗜麦芽窄食单胞菌主要来源于呼吸道痰标本,占80.0%,主要分布于ICU(35.7%)、神经外科(12.9%)和呼吸内科(11.4%)。临床分离的嗜麦芽窄食单胞菌对常见抗生素的总耐药率为复方新诺明7.1%、左氧氟沙星24.3%、头孢他啶79.3%、替卡西林/克拉维酸71.4%。结论该院嗜麦芽窄食单胞菌感染者主要集中在ICU和神经外科,以呼吸道感染居多。对复方新诺明和左氧氟沙星有较高的敏感性,但对头孢他啶和替卡西林/克拉维酸耐药性较高。

Objective To investigate the clinical distribution and drug resistance characteristics of Stenotrophomonas maltophilia （S.maltophilia）strains,aiming to provide guidelines for the clinical prevention and treatment of S.maltophilia and control of nosocomial infection.Methods A total of 1 40 S.maltophilia strains isolated from various clinical specimens from July 201 1 to June 201 4 were cultured,identified and tested for drug sensitivity by using Microscan microbial identification and subjected to antibiotic resistance analysis. The data analysis was performed by WHONET V5.5.Results Approximately 80.0% of S.maltophilia strains were detected from the respiratory tract phlegm samples,mainly distributed in intensive care unit （ICU） （35.7%）,neurosurgery department （1 2.9%）,and respiratory department （1 1 .4%）.The overall resistance rate of 1 40 isolated strains to compound sulfamethoxazole was 7.1 %,24.3% for levfloxacin,79.3% for ce-phradine and 71 .4% for ticarcillin/clavulanate.Conclusions Most of the S.maltophilia were isolated from ICU and neurosurgery department in our hospital,dominantly from respiratory tract infection.S.maltophilia stains had relatively high sensitivity to compound sulfamethoxazole and levloxacin,and were relatively highly resistant to cephradine and ticarcillin/clavulanate.