摘要
神经系统副肿瘤综合征(PNS)是指机体恶性肿瘤或潜在的恶性肿瘤所产生的间接或远隔效应,导致的神经系统病变。它可影响神经系统的任何一个部位,中枢神经系统、周围神经、神经—肌肉接头处或肌肉均可出现病变,症状和体征是多种多样的,主要取决于受损的部位。因此临床表现不典型、多样化,易导致早期漏诊、误诊。本文回顾总结近2年来我院确诊的4例PNS患者,并复习近年国内外相关文献,探讨其临床特征,为PNS的早期诊断,减少误诊提供依据。
出处
《新疆医学》
2015年第4期526-527,517,共3页
Xinjiang Medical Journal
参考文献13
-
1Graus F,Delattre TY, Antoine JC,et al.Recommended diagnostic cri- teria for paraneoplastic neurological syndrome [J]. J Neurol Neurousurg Psychiatry, 2004,75 : 1135.
-
2Hiasa Y, Kunishinge M, Mitsui T,et al. paraneoplastie neurological disorders in breast cancer.Complicated paraneoplastic neurological syndrome:a report of two patients with small cell or non-small cell lung cancer [J]. Clin Neurol Neurosurg, 2003,106 ( 1 )47-49.
-
3Musunuru K,Damell RB. Paraneoplastie neurological disease anti- gem: RNA-binding proteins and signaling proteins in neuronal degen- eration [J]. Annu Rev Neurosci,2001,24:239-262.
-
4Damell RB, Posner JB, Paraaeoplasfic syn-dromes involving the nervous system [J]. N Engl JM ed,2003,349: 1543-1554.
-
5Dropcho EJ. Remote neurologic manifestations of cancer [J]. Neuril Clin, 2002,20( 1 ) : 85-122.
-
6Seute T,LIeffers P,ten Velde G,et al.Neurologic disorders in 432 con- secutive patients with small cell lung carcinoma [J]. Cancer,2004,100 ( 4 ) : 801-806.
-
7Rojas I, Rousseau A,Keime F,et al. Spectrum of paraneoplasfie neuro- logic disorders in women with breast and gynecologic cancer [J]. Medicine, 2003,82 ( 3 ) : 216-223.
-
8Vemino S, LermonVA,Autoanfibody profdes and neurological correla- tions of thymoma [J]. Clin Cancer Res, 2004,10(21 ) :7270-7272.
-
9王湘,白春梅.神经系统副肿瘤综合征的研究进展[J].癌症进展,2011,9(1):58-62. 被引量:17
-
10丛璐,蒲传强.胸腺瘤副肿瘤综合征的临床特征——附4例报告[J].中国神经精神疾病杂志,2012,38(2):97-100. 被引量:3
二级参考文献47
-
1石强,黄旭升,田成林,于生元,管维平,吴卫平,蒲传强.僵人综合征的临床及电生理特点[J].中华神经医学杂志,2005,4(7):720-722. 被引量:3
-
2郭秀海,王玉平,贾建平,张雁华,李宁,李存江,董会卿,吴卫平.僵人综合征及僵人叠加综合征六例的临床特点及丙种球蛋白疗效观察[J].中华神经科杂志,2006,39(4):246-249. 被引量:22
-
3朱峰,费贵军,钱家鸣.胸腺瘤病例回顾分析[J].基础医学与临床,2006,26(8):897-901. 被引量:4
-
4Voltz R.Intravenous immunoglobulin therapy in paraneoplastic neurological syn-drome[J].J Neurol,2006,253(Suppl 5):v33.
-
5Posner JB.Neurologic complications of cancer[M].Philadelphia,USA:FA Davis Company,1995.
-
6Darnell RB.Onconeural antigens and paraneoplastic neurologic disorders:At the intersection of cancer,immunity,and the brain[J].Proc Natl Acd Sci USA,1996,93:4529.
-
7Darnell RB,Furneaux HM,Posner JB.Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells,cortical neurons and neuroectodermal tumors[J].J Neurosci,1991,11:1224.
-
8Sissel EM,Anette K,Helga B,et al.Onconeural antibodies in sera from patients with various types of tumors[J].Cancer Immunol Immunother,2009,58:1795.
-
9Kim YI.Passively transferred Lambert-Eaton syndrome in mice receiving purified IgG[J].Muscle Nerve,1986,9:523.
-
10Sommer C,Weishaupt A,Brinkhoff J,et al.Paraneoplastic stiff-person syndrome:Passive transfer to rats by means of IgG antibodies to amphiphysin[J].Lancet,2005,365:1406.
共引文献18
-
1崔建平.副肿瘤综合征3例分析[J].中国当代医药,2011,18(33):138-139.
-
2肖静,刘丽英,伍妘,韩彤立,王旭.儿童神经系统副肿瘤综合征12例临床分析[J].中华儿科杂志,2012,50(8):598-600. 被引量:7
-
3周昊,杨欢.中枢神经系统自身免疫疾病相关抗体[J].国际神经病学神经外科学杂志,2013,40(3):289-293. 被引量:5
-
4庞爱兰,文薇,孟步亮.148例急性非创伤性肢体无力性疾病的诊断[J].山东医药,2013,53(47):21-23.
-
5王英南,吴忱思,张瑞星.胃癌合并神经系统副肿瘤综合症1例报道及文献复习[J].实用癌症杂志,2014,29(5):564-565.
-
6刘丹,范颖,张海南,张长杰.以副肿瘤性脑脊髓炎为首发症状的肺癌1例报告[J].临床神经病学杂志,2015,28(2):158-159. 被引量:2
-
7范耀东,杨慧勤.肿瘤合并神经系统副肿瘤综合征的诊治[J].中国临床医生杂志,2016,44(7):4-8. 被引量:4
-
8黄宝和,是明启,邵春香.副肿瘤性周围神经病18例临床特点分析[J].中国实用医刊,2016,43(17):17-19.
-
9邵龙,王威,郑娜,蒋胶胶,张家堂.自身免疫性脑炎治疗进展[J].解放军医学杂志,2017,42(4):347-353. 被引量:28
-
10郑克非,单希征,刘金梅,高云.以眩晕为首发症状的副肿瘤综合症1例报告[J].北京医学,2017,39(8):893-894.
同被引文献51
-
1郑奎宏,马林,史丽静,郭勇,黄敏华,张燕群,赵书臣.肿块样原发性中枢神经系统血管炎的磁共振表现[J].中国临床医学影像杂志,2010,21(11):761-764. 被引量:15
-
2高晓梅,张亚丽.多发性硬化的磁共振成像特点[J].中国全科医学,2007,10(22):1913-1914. 被引量:6
-
3Jun Wang,Dali Li,Baocheng Wang,Yun Wu.Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy[J]. Breast Cancer Research and Treatment . 2013 (2)
-
4Jun Wang,Baocheng Wang,Jingwang Bi,Cong Zhang.??Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer(J)Medical Oncology . 2011 (1)
-
5Steven Vernino,Eric R. Eggenberger,Lisa R. Rogers,Vanda A. Lennon.??Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma(J)Neurology . 2002 (6)
-
6Claudia F. Lucchinetti,David W. Kimmel,Vanda A. Lennon.??Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies(J)Neurology . 1998 (3)
-
7J. Hammack MD,H. Kotanides MS,M. K. Rosenblum,J. B. Posner.??Paraneoplastic cerebellar degeneration: II. Clinical and immunologic findings in 21 patients with Hodgkin?s disease(J)Neurology . 1992 (10)
-
8Wang Jun,Zhao Weipeng,Guo Yan,Zhang Bicheng,Xie Qichao,Xiang Debing,Gao Jianfei,Wang Baocheng,Chen Zhengtang.The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis. Oncology . 2009
-
9Okagbue Uchenna E,Wang Luke Y J,Cymet Tyler,Rabin Bruce,Erlich Rodrigo B.A rare case of anti-Hu paraneoplastic neurologic syndrome in association with cervical cancer. Comprehensive Therapy CT . 2008
-
10Wang J,Guo Y,Chu H,et al.Multiple functions of the RNAbinding protein HuR in cancer progression,treatment responses and prognosis. Int J Mol Sci . 2013
引证文献2
-
1甄杰,高杰,张明,邵继文.类固醇激素反应性慢性淋巴细胞性炎症伴脑桥血管周围强化症的鉴别诊断[J].医学综述,2017,23(19):3878-3882. 被引量:1
-
2马增霞,关雅萍,张先欣,王俊,王宝成,荣学东,胡华.非小细胞肺癌外周血抗Hu抗体水平与远处转移的相关性[J].中国肿瘤生物治疗杂志,2015,22(4):500-503. 被引量:2
二级引证文献3
-
1段梅梅,付佳佳.CA125、CEA、CA724和P53检测诊断非小细胞肺癌脑转移的价值分析[J].现代医院,2016,16(11):1611-1613. 被引量:10
-
2熊海林,孙爱华,周思维.联合检测CXCR4与E-Cad在非小细胞肺癌中的表达与脑转移的相关性研究[J].现代诊断与治疗,2017,28(1):1-3. 被引量:8
-
3于进超,王黎明,王鹏飞,赵旭龙,李振芝.CLIPPERS综合征MRI表现一例[J].影像诊断与介入放射学,2023,32(3):226-228.
-
1石纳,侴京梅.1例乳腺癌致神经系统副肿瘤综合征的护理[J].护理研究(中旬版),2009,23(2):467-467.
-
2李会敏,王德超,陈立英,张平,王晔兴,周斌.肺癌致神经系统副肿瘤综合征21例分析[J].中国误诊学杂志,2002,2(4):617-618.
-
3许荣家.鼻咽癌患者的神经系统病变[J].山东医药,1997,37(2):45-46. 被引量:1
-
4彭爱华,洪文德,罗绍凯.误诊为神经系统病变的多发性骨髓瘤9例报告[J].中国神经精神疾病杂志,1995,21(5):298-299. 被引量:2
-
5迟玉丽,宫峰岩,武焕玲.以神经系统病变为首发症状的恶性血液病五例[J].上海医学,2002,25(9):558-558.
-
6王桂华,廖遇平,彭光春,刘凡,李文政,雷光武.大脑胶质瘤病的MRI特点研究[J].中华神经医学杂志,2007,6(10):1002-1004. 被引量:2
-
7李菁晶,鞠奕,赵性泉.副肿瘤综合征神经系统表现19例临床分析[J].中国全科医学,2001,4(9):749-750. 被引量:3
-
8李军,张保东,陈同波.副肿瘤综合征13例临床分析[J].中国实用神经疾病杂志,2008,11(11):94-95. 被引量:2
-
9王婷玉,李俊.凋亡抑制蛋白的研究进展[J].安徽医药,2005,9(6):402-406. 被引量:8
-
10任芳,李小平,魏丽惠.妇科恶性肿瘤脑转移的诊治进展[J].中国妇产科临床杂志,2014,15(5):475-477.