成骨细胞中非核效应信号转导机制的研究进展

Research progress in signal transduction mechanisms of non-nuclear effects in osteoblasts

雌激素缺乏是导致骨质疏松的重要原因之一。雌激素治疗骨质疏松症的临床疗效已获得普遍认可,其抗骨质疏松的作用,主要是通过促进成骨细胞增殖而产生效应。关于雌激素促成骨细胞的增殖,区别于经典的核效应,由雌激素膜受体介导的非核效应已成为研究热点。然而目前成骨细胞中非核效应的信号转导机制尚存争议。非核效应在成骨细胞中具体通过何种路径如ERK/MAPK通路、PI3K/Akt通路、Ca2+通路及新型雌激素受体GPER介导的信号通路产生效应尚无统一认识。故本文就目前已提出的非核效应信号转导途径学说及研究进展进行介绍。

Estrogen deficiency is one of the important causes of osteoporosis .The curative effect of estrogen in the clinical treatment of osteoporosis has won the general recognition .Its anti-osteoporosis effect is mainly through the effect on osteoblast proliferation .Different from the classic nuclear effects , non-nuclear effect mediated by estrogen receptor becomes the hot topics currently in the contribution of estrogen to osteoblast proliferation.However , the signal pathway mechanism of non-nuclear effect in osteoblast is still controversial . The signal pathways include ERK/MAPK pathway , PI3K/Akt pathway , Ca2＋pathway and a novel estrogen receptor signaling pathway mediated by GPER .There is not unified understanding in which is the right signal pathway that make non-nuclear effect in osteoblasts .Thus this paper introduces the signal transduction theories of non-nuclear effects and the research progress in recent years .