摘要
ObjectivesTo 在一个基于社区的队在动脉的僵硬与改变调查血浆 homocysteine 层次的协会。在这些协会的性差别是评估的 examined.MethodsWe 在到三的血浆 homocysteine 层次之间的关系脉管的功能测量[颈动脉大腿骨的脉搏波浪速度(CF-PWV ) ，颈动脉脚关节 PWV (CA-PWV ) 和心率改正了扩大索引(AI )] 在 1680 个参加者(吝啬的年龄：61.5 年；709 个男人， 971 个女人) 从北京的社区， China.ResultsIn univariate 分析，血浆 homocysteine 层次断然与 CF-PWV 有关(r = 0.211， P <；0.0001 ) 并且 CA-PWV (r = 0.148， P <；0.0001 ) 而相反地与 AI 联系了(r =−； 0.052， P = 0.016 ) 。在为 covariants 调整的多重线性回归模型，血浆 homocysteine 与 CF-PWV 有关断然留下了(标准化 β；= 0.065， P = 0.007 ) 在全部的情况中。当男人和女人的组独立被检查时，血浆 homocysteine 仍然保持断然与 CF-PWV 联系了(标准化 β；= 0.082， P = 0.023 ) 而在动脉的僵硬索引的 homocysteine 和任何东西之间的关系是，别在 women.ConclusionsIn 汉语人口在男人推进现在，血浆 homocysteine 层次独立地在男人然而并非在女人与大动脉僵硬的改变被联系。
Objectives To investigate the associations of the plasma homocysteine levels with the alterations in arterial stiffness in a commu- nity-based cohort. The gender differences in these associations were examined. Methods We evaluated the relationship between plasma homocysteine levels to three measures of vascular ftmction [carotid-femoral pulse wave velocity （CF-PWV）, carotid-ankle PWV （CA-PWV） and heart rate corrected augmentation index （AI）] in 1680 participants （mean age： 61.5 years; 709 men, 971 women） from communities of Beijing, China. Results In univariate analysis, plasma homocysteine levels was positively related to the CF-PWV （r = 0.211, P 〈 0.0001） and CA-PWV （r = 0.148, P 〈 0.0001）, whereas inversely associated with AI （r = -0.052, P = 0.016）. In multiple linear regression models adjusting for covariants, plasma homocysteine remained positively related to the CF-PWV （standardized 13 = 0.065, P = 0.007） in total cases. When the groups of men and women were examined separately, plasma homocysteine remained positively associated with the CF-PWV （standardized β = 0.082, P = 0.023） in men, whereas the relations between homocysteine and any of the arterial stiffness indices were not further present in women. Conclusions In Chinese population, plasma homocysteine levels are independently associated with alterations of large artery stiffness in men but not in women.
基金
This work was supported by grants from the Key National Basic Research Program of China （2012CB517503, 2013CB530804） and Nature Science Foundation of China （81270941） to Ye P, and the Nature Science Foundation of China （81100878） and the Beijing Nova Program （Z121107002513124） to Bai Y. The authors have no conflict of interest to declare.
