成都地区高尿酸血症年青化趋势分析

Trend analysis of prevalence of hyperuricemia in young adults in Chengdu

目的对成都地区2011年1月至2014年8月青年群体高尿酸血症（hyperuricemia,HUA）状况及发展趋势进行回顾性分析。方法 2011年1月至2014年8月成都地区健康体检人群共计为86 779名,分为青年组和中年组、老年组进行分析。青年组年龄为18~39岁,平均年龄（28.49±5.78）岁;中年组年龄40~59岁,平均年龄（48.52±6.74）岁。老年组年龄60~87岁,平均年龄（67.22±5.81）岁。高尿酸血症诊断标准：男性≥420μmol/L,女性≥357μmol/L。采用SPSS 17.0软件对数据进行统计学分析,P〈0.05为差异有统计学意义。结果总体人群HUA阳性率为16.29%,4年中呈逐年升高（χ^2=133.36,P〈0.05）;HUA阳性率比较：男性青年组大于中年组、老年组（χ^2=107.31,P〈0.05）;女性青年组小于女性中年组、老年组（χ^2=591.93,P〈0.05）;男、女性青年组各自的HUA阳性率呈逐年上升趋势（男r=0.988,P〈0.05;女r=0.985,P〈0.05）。尿酸水平的比较：男性青年组与中年组比较（t=0.288,P〉0.05）、与老年组比较（t=0.180,P〉0.05）尿酸水平均差异无统计学意义;女性青年组与中年组比较（t=-0.303,P〉0.05）、与老年组比较（t=-0.535,P〉0.05）尿酸水平差异无统计学意义;青年组HUA尿酸水平连续4年无差异性改变（男：t=0.003,P〉0.05;女：t=0.005,P〉0.05）。结论本研究HUA年青化趋势明显,男性青年群体无论HUA阳性率及尿酸水平均大于或等于整体人群;男、女青年组的HUA阳性率与尿酸水平的逐年递增应引起高度关注。为提高全民身体素质,对于HUA年青化的状态及其进展,还需长期关注和研究。

Objective To understand the prevalence of hyperuricemia（HUA）among young adults in Chengdu from January 2011 to August 2014,and to analyze the trend of prevalence. Methods A total of 86 779 healthy check up individuals were surveyed and divided into three age groups,including young adult group（18-39 years old）,middle-aged group（aged 40-59）and senior group（60-87 years old）from January 2011 to August 2014 in Chengdu.HUA was determined if serum uric acid level was above 420μmol/L for males and 357μmol/L for females.SPSS 17.0software was used for data processing. Results The overall prevalence of HUA was 16.29%,which significantly increased in 4years（χ^2=133.36,P〈0.05）.Among male participants,the positive rate of HUA was the highest in young adult group（χ^2=107.31,P〈0.05）,while,it was the lowest among female ones（χ^2=591.93,P〈0.05）.The positive rates of HUA in both young male and female groups showed an upward trend in 4years（r=0.988 for male,P〈0.05;r=0.985 for female,P〈0.05）.There were no significant differences of serum uric acid levels among both male and female age groups（P〉0.05）,which remained almost unchanged during 4year study period（P〉0.05）. Conclusions There is a trend of more young adults with HUA,especially among males.The prevalence of HUA increases in both male and female young adults,which should be highly concerned.