摘要
目的研究分析阿仑膦酸钠对绝经后骨质疏松患者的临床疗效。方法将125例绝经后骨质疏松患者随机分为对照组和观察组,对照组每天口服等量元素钙600 mg;观察组在对照组基础上给与阿仑膦酸钠80 mg,1次/周,连续治疗1年后,检测骨密度,研究临床疗效。结果观察组和对照组的显效率分别为71.0%和44.4%,有效率分别为24.2%和27.0%,总有效率分别为96.5%和71.4%,差异均具有统计学意义(P〈0.05)。治疗前,对照组腰椎1-4、股骨颈、股骨大转子及全髋BMD值分别为(0.861±0.142)、(0.717±0.104)、(0.590±0.056)、(0.783±0.097),观察组相应部位的BMD值分别为(0.863±0.101)、(0.716±0.102)、(0.588±0.062)、(0.775±0.096)。治疗后,对照组相应部位的BMD值分别为(0.896±0.127)、(0.726±0.085)、(0.599±0.059)、(0.783±0.097),观察组相应部位的BMD值分别为(0.919±0.115)、(0.737±0.093)、(0.605±0.045)、(0.789±0.098)。接受1年治疗后,2组腰椎1-4、股骨颈、股骨大转子及全髋BMD值均有明显增加,与治疗前比较差异均具有统计学意义(P〈0.05)。且观察组骨密度增加更明显,2组差值比较具有统计学意义(P〈0.05)。结论阿仑膦酸钠对于短期治疗绝经后骨质疏松患者是有效的。
Objective To study the clinical efficacy analysis of Allen phosphonic acid sodium in patients with postmenopausal osteoporosis. Methods 125 postmenopausal osteoporosis patients were randomly divided into control group and the observation group, control group were given oral equivalent element 600 mg of calcium. Observation group is given 600 mg of calcium and Allen phosphonic acid sodium 80 mg, one time per week, bone density after 1 year in a row were detected to study the clinical curative effect. Results The efficiency rates of the observation group and the control group were 71.0% and 44.4%, effective rates were 24.2% and 27.0% respectively, the total effective rates were 96.5% and 71.4%, the differences were statistically significant (P〈0.05). Before the treatment, lumbar 1-4, femoral neck, femoral greater trochanter and total hip BMD of control group were (0.861±0.142), (0.717±0.104), (0.590±0.056), (0.783±0.097), those of observation group were (0.863±0.101), (0.716+0.102), (0.588±0.062), (0.775±0.096).After treatment, those of control group were (0.896±0.127), (0.726±0.085), (0.599±0.059), (0.783+0.097), those of observation group were (0.919±0.115), (0.737±0.093), (0.605±0.045), (0.789±0.098). One year after treatment, BMD of lumbar 1-4, femoral neck, femoral greater trochanter and total hip in two groups were significantly increased, compared with before treatment differences were statistically significant(P〈0.05). Bone mineral density increased more obviously and the difference between the two groups (P〈0.05). Conclusion Alendronate phosphonic acid sodium for short-term treatment of postmenopausal osteoporosis patients is effective.
出处
《当代医学》
2015年第18期51-52,共2页
Contemporary Medicine
关键词
阿仑膦酸钠
骨质疏松
骨密度
Allen phosphonic acid sodium
Osteoporosis
Bone mineral density