阿奇霉素联合莫西沙星治疗支原体肺炎70例临床分析

目的探讨阿奇霉素联合莫西沙星治疗支原体肺炎的疗效。方法将138例支原体肺炎患者分为2组,观察组70例给予阿奇霉素联合莫西沙星治疗,对照组68例给予单纯阿奇霉素治疗。对照组采用单纯的阿奇霉素片进行治疗,首次服用剂量为0.5 g,以后降为0.25 g/d,顿服。观察组在对照组基础上联合使用莫西沙星片进行治疗,400 mg/d,顿服。2组患者连续治疗2周为1个疗程。结果观察组、对照组总有效率分别为97.14%、76.47%,观察组总有效率高于对照组,差异有统计学意义(P<0.05);发热缓解时间(1.89±0.51)d、肺部啰音消失时间(4.13±1.72)d、咳嗽改善时间(4.00±1.41)d短于对照组,差异有统计学意义(P<0.05);2组不良反应发生率比较差异无统计学意义。结论阿奇霉素联合莫西沙星治疗支原体肺炎,可提高疗效,有效改善体征与临床症状,不良反应少。

Objective To investigate the efficacy of moxifloxacin in treatment of mycoplasma pneumoniaazithromycin. Methods 138 cases of mycoplasmal pneumonia patients were divided into two groups. 70 cases in the observation group were given azithromycin plus the moxifloxacin treatment, 68 cases in the control group weretreated with azithromycin treatment. Results Total effective rate of observation group, the control group were 97.14%, 76.47%, the total effeetive rate of observation group was higher than that of the control group; fever, pulmonary rales, cough improved time shorter than the control group, there was significant difference between two groups （P 〈 0.05）; the incidence of the adverse reactions between the two groups had no statistical significance. Conclusion Azithromycin combined with moxifloxacin in treatment ofmycoplasma pneumonia, can improve the curative effect, improve the clinical symptoms and signs, less adverse reaction.