期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

骨髓间充质干细胞成骨分化研究进展 被引量：3

下载PDF
导出
摘要 骨髓间充质干细胞是一类具有多向分化潜能的干细胞,可作为种子细胞,修复和重建损伤或发生病变的多种组织器官,在再生医学领域中具有潜在的应用前景。在其向成骨方向的分化过程中,由多种通路、多种因子参与,其中包括细胞因子、生长因子和激素等。本文对骨髓基质干细胞的成骨分化进行了综述。
作者 胡楠 刘洪臣
机构地区 解放军总医院口腔医学研究所
出处 《口腔颌面修复学杂志》 2015年第3期174-177,共4页 Chinese Journal of Prosthodontics
基金 国家自然科学基金(项目编号:81271180) 全军医学科技"12.5"重大项目(项目编号:AWS11J012-04) 首都临床特色应用研究(项目编号:jfjz 2013-)
关键词 骨髓间充质干细胞 MAPKS信号通路 骨质疏松
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献38

  • 1Pittenger M F, Mackay A M, Beck S C, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999, 284(5411): 143-147.
  • 2Jiang Y, Jahagirdar B N, Reinhardt R L, et al. Pluripo- tency of mesenchymal stem cells derived from adult marrow [J]. Nature, 2002, 418(6893): 41-49.
  • 3Garcia-Gomez I, Elvira G, Zapata AG, et al. Mesenchy- mal stem cells: biological properties and clinical applications [Jl. Expert Opin BiolTher, 2010, 10(10): 1453-1468.
  • 4Myers T J, Granero-Molto F, Longobardi L, et al. Mes- enchymal stem cells at the intersection of cell and gene thera- py[J]. Expert Opin Biol Ther, 2010, 10(12): 1663-1679.
  • 5Martin TJ. Bone biology and anabolic therapies for bone: Current status and future prospects [J]. Bone Metab, 2014, 21(1): 8-20.
  • 6Lacey DL, Boyle W J, Simonet WS, et al. Bench to bed- side: Elucidation of the OPG-RANK- RANKL pathway and the development of denosumab[J]. Nat Rev Drug Dis- coy, 2012, 11:401-419.
  • 7O' Brien CA, Nakashima T, Takayanagi H. Osteocyte control of osteoclastogenesis[J]. Bone, 2013, 54(2): 258-263.
  • 8Rossini M, Gatti D, Adami S. Involvement of WNT/be- ta-catenin signal- ing in the treatment of osteoporosis[J]. CalciITissuelnt, 2013, 93(2): 121-132.
  • 9Giustina A, Mazziotti G, Canalis E. Growth hormone, in- sulin-like growth factors, and the skeleton[J]. Endocr Rev, 2008, 29(5)I 535-559.
  • 10Zhou S. TGF-beta regulates beta-catenin signaling and os- teobhast differentiation in human mesenchymat stem ceUs[J]. J CeUBiochem, 2011, 112(6): 1651-1660.

二级参考文献35

  • 1廖清船,肖洲生,秦艳芳,赵彦,潘玮,刘霆,周宏灏.p44/42和p38 MAPKs在骨髓间充质干细胞向成骨细胞分化中发挥不同的功能[J].中国骨质疏松杂志,2004,10(3):267-271. 被引量：22
  • 2潘海涛,郑启新,郭晓东,刘勇.兔骨髓基质干细胞的分离培养和鉴定及转化生长因子β1的基因瞬时转染研究[J].医学研究生学报,2006,19(6):508-511. 被引量：9
  • 3Fujioka D,Nakamura S,Yoshino H,et al.Expression of endothelins and their receptors in cells from human periodontal tissues[J].J Periodontal Res,2003,38(3):269-275.
  • 4Rogers JE,Li F,Coatney DD,et al.A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model.J Periodontol,2007,78(10):1992-1998.
  • 5Jonsson D,Nilsson J,Odenlund M,et al.Demonstration of mitochondrial oestrogen receptor beta and oestrogen-induced attenuation of cytochrome c oxidase subunit I expression in human periodontal ligament cells[J].Arch Oral Biol,2007,52(7):669-676.
  • 6Yanagisawa M,Kurihara H,Kimura S,et al.A novel potent vasoconstrictor peptide produced by vascular endothelial cells[J].Nature,1988,332:411-415.
  • 7Guan SM,Zhang M,He JJ,et al.Mitogen-activated protein kinases and phosphatidylinositol 3-kinase are involved in Prevotella intermedia-induced proinflammatory cytokines expression in human periodontal ligament cells[J].Biochem Biophys Res Commun,2009,386(3):471-476.
  • 8Kook SH,Jang YS,Lee JC.Involvement of JNK-AP-1 and ERK-NF-κB signaling in tension-stimulated expression of type I collagen and MMP-1 in human periodontal ligament fibroblasts[J].J Appl Physiol,2011,111(6):1575-1583.
  • 9Zhang D,Zheng H,Zhao J,et al.Porphorymonas gingivalis induces intracellular adhesion molecule-1 expression in endothelial cells through the nuclear factor-kappaB pathway,but not through the p38 MAPK pathway[J].J Periodontal Res,2011,46(1):31-38.
  • 10Hauselmann H J,Rizzoli R.A comprehensive review of treatments for postmenopausal osteoporosis[J].Osteoporos Int,2003,14:2-12.

共引文献19

同被引文献51

  • 1Liu E Y, Wactawski-Wende J, Donahue R P, et al. Does low bone mineral density start in post-teenage years in women with type 1 diabetes?[J]. Diabetes Care, 2003, 26(8): 2365-2369.
  • 2Montagnani A, Gonnelli S, Alessandri M, et al. Osteoporosis and risk of fracture in patients with diabetes: an update[J]. Aging Clin Exp Res, 2011, 23(2): 84-90.
  • 3Shen W, Chen J, Gantz M, et al. MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults[J]. Eur J Clin Nutr, 2012, 66(9): 983-988.
  • 4Bredella M A, Torriani M, Ghomi R H, et al. Vertebral bone marrow fat is positively associated with visceral fat and in- versely associated with IGF-1 in obese women [J]. Obesity (Silver Spring), 2011, 19(1): 49-53.
  • 5Xu C, Wang J, Zhu T, et al. Cross-Talking Between PPAR and WNT Signaling and its Regulation in Mesenchymal Stem Cell Differentiation[J]. Curr Stem Cell Res Tiler, 2016,11(3): 247-254.
  • 6Yuan Z, Li Q, Luo S, et al. PPARgamma and Wnt Signaling in Adipogenic and Osteogenic Differentiation of Mesenchy- real Stem Cells[J].Curr Stem Cell Res Tiler, 2016, 11 (3): 216-225.
  • 7Palicka V, Lesna J, Pavlikova L. [Changes of bone metabolism in diabetics][J]. Vnitr Lek, 2014, 60(9): 742-745.
  • 8Zhang B, Liu N, Shi H, et al. High glucose microenviron- ments inhibit the proliferation and migration of bone mes- enchymal stem cells by activating GSK3beta[J]. J Bone Miner Metab, 2016, 34(2): 140-150.
  • 9Chang T C, Hsu M F, Wu K K. High glucose induces bone marrow-derived mesenchymal stem cell senescence by up- regulating autophagy[J]. PLoS One, 2015, 10(5): e126537.
  • 10Wang W, Zhang X, Zheng J, et al. High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular sig- nal-regulated kinase pathway[J]. Mol Cell Biochem, 2010, 338(1-2): 115-122.

引证文献3

二级引证文献7

口腔颌面修复学杂志
2015年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部