博尔宁胶囊联合化疗治疗晚期胃癌的临床研究

Clinical Study of Chemotherapy Plus Boerning Capsules for Advanced Gastric Cancer

目的:明确博尔宁胶囊联合替吉奥治疗晚期胃癌患者的疗效、生活质量及毒副作用。方法:将60例晚期胃癌患者随机分为两组:实验组30例(博尔宁胶囊联合替吉奥治疗组);对照组30例(替吉奥单药治疗组)。比较二组患者的治疗效果、生活治疗及毒副反应。结果:实验组治疗有效率为56.67%,对照组治疗有效率为36.67%。实验组患者经治疗后毒副反应发生率低(P<0.05),且生活质量高于对照组(P<0.05)。结论:博尔宁胶囊联合替吉奥治疗晚期胃癌患者可提高治疗效果,降低化疗毒副反应的发生率,提高患者生活质量。

Objective：To evaluate the efficacy, toxicity and adverse reactions of S-1 alone or in combination with Boerning capsules for advanced gastric cancer. Methods：Sixty patients with advanced gastric cancer were randomly divided into two groups： trial group （n=30） received Boeming capsules and S-l, and control group （n=30） only accepted chemotherapy. The response rate, toxicity and quality of life （QQL） were compared in two groups. Results：There were differences between the trial group and the control group in response rate （ 56.67% and 36.67%,P〈0.05） , and the trial group had milder adverse reactions yet better improvement of symptoms than in the control group （ P〈0.05）. Conclusion：Addition of Boeming capsules to S-1 resulted in better efficacy yet milder adverse reactions of chemotherapy and better quality of life in patients with advanced gastric cancer.