4-异丁基苯乙酮加氢-羰基化合成布洛芬

Synthesis of Ibuprofen by Hydrogenation-carbonylation of 4-Isobutyl Acetophenone

采用CuO-ZnO/Al2O3纳米铜基催化剂催化4-异丁基苯乙酮(IBAP)加氢制备1-(4-异丁基苯基)乙醇(IBPE);然后以PdCl2/PPh3/CuCl2为催化体系,将IBPE经羰基化反应合成2-(4-异丁基苯基)丙酸(布洛芬)。研究结果表明:在反应温度80℃,氢气压力1.5MPa,n(H2)∶n(IBAP)=40∶1,液空速0.30h-1的条件下,IBAP的加氢转化率为100%,IBPE收率达到93.6%。以盐酸为酸性介质、丁酮为溶剂,在温度100℃,CO压力5.5 MPa,反应时间24h的条件下,IBPE羰基化合成布洛芬,IBPE的转化率为100%,布洛芬收率达到72.9%。

4-Isobutyl acetophenone （IBAP） was hydrogenated to 1-（4-isobutyl phenyl） ethanol （IBPE） on nano CuO-ZnO/A1203 catalyst, and then 2-（4-isobutyl phenyl） pro- pionic acid （ibuprofen） was prepared by carbonylation of IBPE with PdClz/PPh3/CuC12 as the catalyst. The results showed that hydrogenation conversion of IBAP approached 100% and the yield of IBPE reached 93.6% under 80 ℃, H2 pressure 1.5 MPa, n（H2） ： n（IBAP）= 40 ： 1 and liquid hourly space velocity 0.30 h-1. Using hydrochloric acid as acid medi- um, butanone as solvent, ibuprofen was prepared by carbonylation of IBPE, conversion of IBPE reached 100% and yield of ibuprofen reached 72.9% under reaction temperature 100 ℃, CO pressure 5.5 MPa, reaction time 24 h.