低密度脂蛋白胆固醇、血糖、吸烟年数与CISS亚型相关性的研究

Study on the Relationships Between LDL-C, Serum Glucose, Years of Smoking and Stroke Subtypes of CISS

目的探讨低密度脂蛋白胆固醇、血糖、吸烟年数与脑梗死CISS亚型的关系。方法回顾性分析急性缺血性脑梗死患者,检测其低密度脂蛋白胆固醇、血糖、吸烟年数,研究其与脑梗死CISS亚型的关系。结果高血糖、吸烟年数均与各亚型的关系并没有特殊差异,低密度脂蛋白胆固醇水平升高与大动脉粥样硬化性脑梗死的发生有显著作用(OR=10.57,P<0.001),与穿支动脉病变性脑梗死有一定的相关性(OR=1.33,P<0.001)。结论不同的脑梗死CISS亚型与不同的危险因素有关,该结果对临床个体化预防与治疗有一定的指示意义。

Objective To explore the relationships between LDL-C, serum glucose, years of smoking and stroke subtypes of CISS. Methods The clinical data of patients with acute cerebral infarction were analyzed retrospectively. Risk factors included low density lipoprotein cholesterol（LDL-C）, serum glucose, years of smoking. The relationships between risk factors and CISS were established by statistics. Results There were no difference in the relationships of hyperglycosemia, year of smoking and subtypes of CISS. High LDL-C had a significant（OR=10.57, P〈0.001）relationship with large artery atherosclerotic cerebral infarction（LAA）, and also was associated with penetrating artery disease（PAD）（OR=1.33, P〈0.001）. Conclusions Different stroke subtypes of CISS were associated with different risk factors, which may indicate us to improve the individual therapy in brain ischemia.