针刺治疗颈动脉粥样硬化斑块疗效及对IL-10水平的影响

Effect of Acupuncture Treatment of Carotid Atherosclerotic Plaque and Interleukin-10

目的:观察针刺对颈动脉粥样硬化斑块转归、脑血管事件及抗炎性因子的影响。方法:观察66例颈动脉粥样硬化斑块患者,随机分为对照组和治疗组各33例,分别观察颈动脉粥样硬化斑块的变化、脑血管事件的发生及对白介素-10(IL-10)水平变化。结果:随诊观察6个月后,治疗组IL-10的水平高于对照组(P<0.05),有显著性差异;治疗组较对照组患者颈动脉斑块发展缓慢,转化为稳定斑块率高(P<0.05),有显著性差异;缺血性脑血管事件发生率低(P<0.05),且有显著性差异。结论:针刺可减缓颈动脉硬化的进程、改善颈动脉粥样硬化的转归,升高IL-10水平,减少脑血管事件的发生。

Objective：To observe the effect of acupuncture on carotid atherosclerotic plaque and the occurrence of cerebrovascular end- point events,and its impact on anti- inflammatory cytokine level. Methods：Sixty- six patients with carotid atherosclerotic plaque were randomly divided into acupuncture group and control group,33 cases in each groups. Changes of carotid atherosclerotic plaque and plasma IL- 10 level,and the occurrence of cerebrovascular end- point events were observed. Results：After 6 months of treatment,the plasma IL- 10 level was significantly higher in the acupuncture group than the control group（P〈0.05）. The carotid atherosclerotic plaques of the acupuncture group progressed slower,with a higher rate of converting to stable plaques compared to the control group（P〈0.05）. The incidence of cerebrovascular end- point events were significantly lower in the acupuncture group than the control group（P〈0.05）. Conclusions：Acupuncture could slow the progression of carotid atherosclerosis,and improve the prognosis of carotid atherosclerosis,and increase the plasma IL- 10 level,and decrease the occurrence of cerebrovascular events.