中西医结合治疗糖尿病肾病Ⅲ期60例

Treatment of 60 Cases of Phase Ⅲ Diabetic Nephropathy by Integrated Chinese and Western Medicine

目的:观察糖肾方联合缬沙坦治疗糖尿病肾病(DN)Ⅲ期的临床疗效。方法:将60例DNⅢ期患者随机分为对照组和治疗组各30例,对照组给予缬沙坦治疗,治疗组在对照组基础上加用糖肾方。两组疗程均为12周。比较两组中医证候、血清β2微球蛋白(β2-MG)及尿微量清蛋白(ALB)的改善情况。结果:治疗组总有效率86.7%,对照组63.3%,两组比较差异有统计学意义(P<0.05)。治疗组治疗后中医证候积分、血β2-MG及尿ALB与治疗前比较差异均有高度统计学意义(P<0.01),与对照组比较差异亦均有高度统计学意义(P<0.01)。结论:糖肾方联合缬沙坦治疗DNⅢ期疗效明显优于单纯西药。

bjective：To observe the efficacy of Tangshen formula combined with Valsartan treating phase Ⅲdiabetic nephropathy（DN）. Methods：Sixty DN patients were randomly divided into the control group and the treatment group,and 30 cases in each group. Patients in the control group received Valsartan. Based on the treatment for the control group,patients in the treatment group were treated with Tangshen formula orally.The treatment course lasted for 12 weeks. The improvement of TCM syndrome,β2- microglobulin and urinary albumin were compared in both groups. Results：The total effective rate in the treatment group was 86.7%,which was 63.3% in the control group respectively,there was significant difference between two groups（P0.05）. There were high statistical significance in the TCM syndrome,β2- microglobulin and urinary albumin before and after the treatment,compared with the control group,those also had high statistical significance（P〈0.01）. Conclusion：Tangshen formula combined with Valsartan showed better effect than western medicine treatment alone in treating phase Ⅲ diabetic nephropathy（DN）.