P16蛋白表达强度与CINⅠ病变转归的相关性研究

Correlation Study between P16 Expression and Prognosis of CIN Ⅰ Lesions

目的：研究P16蛋白表达强度与宫颈上皮内瘤样病变（CINⅠ病变）转归的相关性。方法：选取2010年5月~2013年2月我院收治的CINⅠ病患者37例为研究对象,进行回顾性分析,进行病理活检与免疫组化,分析随访期间与随访结束时病理检查患者病变转归结局。结果：37例患者中,P16蛋白阳性检出率为51.35%,其中阳性（＋）29.73%,阳性（＋＋）16.21%,阳性（＋＋＋）5.50%;37例患者随访期间病变进展患者5例,比例13.51%,阴性组患者未见病情进展,随着P16蛋白表达增强,病变进展率逐步增加,对比差异具有统计学意义（P〈0.05）;以P16蛋白表达强度做预测CIN病变指标,灵敏度、特异度、阳性预测值及阴性预测值均较佳。结论：P16蛋白表达强度可有效预测CINⅠ病变转归情况,对指示患者病情进展有积极意义,临床应用价值高,可作为评价CINⅠ病变进展的重要参考指标。

Objective： To study the expression of P16 protein correlation between strength and CIN Ⅰ lesions.Methods： From 2010 May to 2013 February in our hospital in patients with CIN Ⅰ disease 37 cases as the object of study were retrospectively analyzed,pathological biopsy and immunohistochemical analysis,the end of the follow-up period and follow-up outcome in patients with pathological examination.Results： In 37 patients,P16 positive detection rate was 51.35%,the positive（＋） 29.73%,16.21% positive（＋ ＋）,5.50% positive（＋ ＋ ＋）; 5 cases,37 cases lesions during follow-up of patients with progression in patients with a proportion of 13.51%,negative group patients had no disease progression,with the enhanced expression of P16 protein,the disease progression rate gradually increased,with significant differences（P〈0.05）; to P16 protein expression to predict CIN disease index,sensitivity,specificity,positive predictive value and negative predictive values were better.Conclusion： P16 protein expression could effectively predict CIN Ⅰ pathological conditions,have a positive significance for the progress indicator of patient＇s condition,with high clinical application value,can be used as an important reference index to evaluate the progress of CIN Ⅰ lesions.