宫颈癌和宫颈上皮内瘤变组织中成纤维活化蛋白α的表达

Expression of fibroblast activation protein α in cervical cancer and cervical intraepithelial neoplasia tissue

目的:检测宫颈癌和宫颈上皮内瘤变(CIN)组织中成纤维活化蛋白α(FAPα)的表达情况。方法:采用免疫组化SP法检测10例宫颈炎、40例CIN及81例宫颈癌组织中FAPα的表达。结果:FAPα在宫颈炎组织中不表达,宫颈癌组织中FAPα阳性表达率高于CIN组织(χ2=81.706,P<0.001)。不同组织学类型(Z=2.069,P=0.039)、淋巴结转移情况(Z=3.382,P=0.001)和浸润深度(Z=2.185,P=0.029)的宫颈癌组织中FAPα表达水平比较,差异有统计学意义。结论:FAPα可能参与了宫颈癌的发生发展。

Aim： To detect the expression of fibroblast activation protein α（ FAPα） in cervical cancer and cervical intraepithelial neoplasia tissue. Methods： FAPα expression in 10 cases of human cervicitis,40 cases of cervical intraepithelial neoplasia and 81 cases of cervical cancer tissue was detected by SP method. Results： FAPα expression was higher in cervical cancer tissue than that in cervical intraepithelial neoplasia tissue（ χ2= 81. 706, P〈0. 001）. FAPα expression in cervical cancer tissue was different with different histopathologic type（ Z = 2. 069,P = 0. 039）,lymph node metastasis（ Z =3. 382,P = 0. 001）,and depth of invasion（ Z = 2. 185,P = 0. 029）. Conclusion： FAPα may take part in invasion and metastasis of cervical cancer.