阿托伐他汀联合速效救心丸对老年冠心病患者血脂及血清炎症因子的影响

Effect of atorvastatin combined Suxiao Jiuxin pills on blood lipid and serum inflammatory factor in elder patients with coronary artery disease

目的:探讨阿托伐他汀联合速效救心丸对老年冠心病患者血脂及血清炎症因子的影响。方法:将194例冠心病患者随机数字法分为2组,每组97例。对照组给予阿托伐他汀,观察组在对照组的基础上加用速效救心丸。治疗1个月,对两组患者治疗前后血脂(TC,TG,HDL-C,LDL-C)、血清炎症因子(TNF-α,CRP,MMP-9,IL-6)及肝肾功指标(ALT,BUN,Scr)进行观察,并进行统计分析。结果:治疗后,两组血脂(TC,TG,HDL-C,LDL-C)水平较治疗前显著改善(P<0.05),观察组血脂(TC,TG,LDL-C)显著低于对照组(P<0.05);治疗后,两组血清炎症因子(TNF-α,CRP、MMP-9,IL-6)水平较治疗前显著降低(P<0.05),观察组血清炎症因子(TNF-α,CRP,IL-6)显著低于对照组(P<0.05);两组治疗前后肝功指标(ALT,BUN,Scr)变化不显著(P>0.05)。结论:阿托伐他汀联合速效救心丸可有效改善老年冠心病患者血脂水平,降低患者血清炎症因子水平,且并不加重肝肾的负担。

Objective： To investigate effect of atorvastatin combined Suxiao jiuxin pills on blood lipid and serum inflammatory factor in elder patients with coronary artery disease. Methods： 194 cases of elderly patients with coronary heart disease were randomly divided into two groups with 97 cases in each group. Patients in control group were given atorvastatin, and patients in observation group were given both atorvastatin and Suxiao jiuxin pills. After treatment for one month, the blood lipid （TC, TG, HDL-C and LDL-C）, serum inflammatory factor （TNF-a, CRP, MMP-9 and IL-6） and liver and renal function （ALT, BUN and Scr） of two groups were statistically analyzed. Results： After treatment, the blood lipid levels （TC, TG, HDL-C and LDL-C） of two groups were significantly improved compared with those before treatment （P〈0.05）, and blood lipid levels （TC, TG and LDL-C） of observation group were significantly lower than control group （P〈0.05）; after treatment, serum inflammatory factor levels （TNF-α, CRP, MMP-9 and IL-6） of two groups were significantly improved compared with before treatment （P〈0.05）, serum inflammatory factor levels （TNF-α, CRP and IL-6） of observation group were significantly lower than control group （P〈0.05）; The liver and renal function levels （ALT, BUN and Scr） before and after treatment of two groups didn＇t change significantly （P〉0.05）. Conclusion： Atorvastatin combined Suxiao jiuxin pills can effectively improve blood lipid level and reduce serum inflammatory factor levels in elder patients with coronary artery disease, but not increase the burden of liver and kidney.