促排卵过程中应用小剂量阿司匹林对改善子宫内膜发育的研究

Research on use of low-dose aspirin in the process of promoting ovulation to improve endometrial development

目的:分析采用小剂量阿司匹林治疗对促排卵期间改善子宫内膜发育的临床价值。方法:收集50例因排卵功能低下而不孕女性患者,分为研究组与对照组,各25例。对照组采用克罗米酚治疗,研究组在克罗米酚治疗的基础上采用阿司匹林(75 mg·d-1)治疗。结果:排卵前1 d,研究组的血栓素A2(TXA2)水平与TXA2/前列环素(PGI2)比值均显著低于对照组;与对照组对比,研究组排卵前1 d的子宫动脉血流RI明显更低,内膜厚度更明显(P<0.05);与对照组对比,研究组排卵后的子宫内膜厚度明显更高(P<0.05);与对照组对比,研究组排卵后10 d的子宫内膜面积、间质面积、腺腔周长及腺/间比值明显更大(P<0.05);与对照组对比,研究组排卵后10 d的子宫内膜ER、子宫内膜PR明显更高(P<0.05)。结论:在排卵期间,采用小剂量阿司匹林治疗,有利于增加子宫血流供应,能有效促进子宫内膜发育、增厚,有利于提高妊娠率。

Objective： To analyze the clinical value of using low-dose aspirin during ovulation to improve endometrial development. Methods： 50 cases of infertility due to ovulatory dysfunction and female patients were collected and divided into study group and control group with 25 caseseach. The control group received clomiphene treatment, and the research group received aspirin （75 mg·d^-1） treatment on the basis of clomiphene. Results： 1 d before ovulation, TXA2 level and TXA2 / PGI2 ratio of study group were significantly lower than those of the control group. Compared with the control group, uterine artery RI in the study group ld before ovulation was significantly lower, with endometrial thickness more significantly obvious（P〈0.05 ）. Compared with the control group, endometrial thickness in the study group after ovulation was significantly higher （P〈0.05）. Compared with the control group, the interstitial area, perimeter and glandular gland / room ratio in the study group 10d after ovulation endometrial area, were significantly greater （P〈0.05）. Compared with the control group, endometrial ER, PR endometrial in the study group 10d after ovulation were significantly higher （P〈0.05）. Conclusion： During ovulation, the use of low-dose aspirin therapy was helpful to increase blood supply to the uterus, promote the development of endometrial thickening, and improve the pregnancy rate.