心血管相关疾病与老年人缺血性结肠炎的相关性研究

The relationship of cardiovascular diseases and ischemic colitis in elderly patients

目的探讨心血管疾病相关疾病与老年人缺血性结肠炎（IC）的相关性。方法收集我科2012年2月～2014年5月44例老年IC患者（均为急性起病）及48例溃疡性结肠炎（UC）患者（均于50岁以后起病）临床资料，对其与心血管疾病的相关性进行分析。结果与老年发病的UC患者相比，老年IC患者冠状动脉粥样硬化性心脏病（以下简称冠心病）、高血压、高脂血症发病率明显偏高（P〈0．01）。多因素回归分析结果提示，高血压病与老年IC发病显著相关[风险比（OR）=3．774，95％可信区间（95％CI）：1．125—12．658，P〈0．05]。在老年IC患者中，高血压病患者较血压正常患者肠道缺血性病变范围更广，横结肠、脾曲累及率明显偏高（P〈0．01）。结论高血压病与老年人缺血性肠病发病有关，且合并高血压病的患者肠道缺血性病变范围更广。

Objective To analyze the risk factors and cardiovascular diseases associated with elderly ischemic colitis（IC）. Methods Retrospective analysis was performed on 44 acute IC cases and 48 ulcerative colitis（UC） cases of elderly onset,both of which were admitted from Feb 2012 to May 2014. Results Compared with UC cases of elderly onset, more elderly IC cases suffered from coronary heart disease （P 〈 0.01 ） , hypertension （ P 〈 0.01 ） and hypedipidemia （ P 〈 0.01 ）. After multivariate logistic regression analyses, hypertension was found to be associated with the onset of elderly IC （ OR = 3. 774, 95% CI： 1. 125-12. 658, P 〈 0.05 ）. Among the elderly IC patients, the cases with hypertension suffered from a more extensive intestinal lesion, especially at transverse colon and splenetic flexure of colon （ P 〈 0.01 ） ,in comparison with the cases without hypertension. Conclusion Hypertension is associated with the development of elderly IC, among which the cases with hypertension tend to have a more extensive intestinal lesion.