CdTe/CdS量子点荧光猝灭法测定盐酸西替利嗪

Determination of Cetirizine Hydrochloride by Fluorescence Quenching of CdTe/CdS Quantum Dots

建立一种基于纳米材料的荧光性质测定盐酸西替利嗪含量的新方法，盐酸西替利嗪能使硫化镉包被的碲化镉核壳型量子点（ CdTe／CdS QDs ）发生规律性的荧光猝灭，研究二者相互作用的最佳条件，从而建立测定盐酸西替利嗪含量的方法。结果表明：盐酸西替利嗪的浓度在0.40～42μg／mL范围内有良好的线性关系（ r＝0.9992），检测限为2.50＆#215;10－2μg／mL，回收率为93.80％～97.00％。结论：此方法简便、快捷、可靠，适用于盐酸西替利嗪的含量测定。

In order to develop a new method based on the fluorescence properties of nanocrystal for the determination of cetirizine hydrochloride , the regular fluorescence quenching of core -shell CdTe/CdS QDs was made by cetirizine hydrochloride , so as to establish the determination method of cetirizine hydrochloride under the best conditions of the interaction.Results showed that there was a linear relationship in the range of 0.40 ~42 μg/mL for cetirizine hydrochloride with the correlation coefficient of 0.9992.The determination limit was 2.50 ＆#215;10-2 μg/mL and the recovery was 93.80%~97.00%.The method is simple , rapid and reliable , and can be used for the determination of cetirizine hydrochloride.