Toll样受体在骨改建中的作用

Advancement of the role of Toll-like receptors in bone reconstruction

Toll样受体(TLR)是一种模式识别受体,在早期固有免疫中对入侵病原微生物的识别发挥重要作用,并在高等脊椎动物的固有免疫和适应性免疫中起着枢纽作用。骨是一种动态性组织,它通过不断地形成和吸收以起到塑形的作用。这种吸收和重建依赖于成骨细胞和破骨细胞的共同作用,这些细胞同时受到多种内外因子的调节作用。近来研究发现,TLR对骨改建也具有重要的调控作用,主要是在成骨细胞及破骨细胞分化、成熟及其功能中发挥作用。阐明TLR调控骨改建的机制将为更有效的正畸牙移动方式提供重要信息,本文将对TLR在骨改建中的作用进行简要综述。

As pattern recognition receptors, Toll-like receptor（TLR） plays an important role in the recognition of invasive pathogenic microorganism in early innate immunity. TLR also plays apivotal role in the innate immunity and adaptive immunity of higher vertebrates. Bone, which belongs to the dynamic organization, plays the role of shaping and maintaining form through continuous formation and absorption. Absorption and reconstruction rely on the combined action of the osteoblast and osteoclast. These cells received accommodation by various internal and external factors. A recent study found that TLR also plays an important role in regulating bone remodeling, primarily in the differentiation as well as the maturation and function of the osteoblast and osteoclast. The study can provide important information for seeking a better method of moving orthodontic tooth by clarifying the mechanism in which TLRs control bone reconstruction. This article reviewed the TLRs＇ role in bone reconstruction.