山西地区食管鳞癌人乳头瘤病毒感染情况研究

Esophageal squamous carcinoma infection status of human papiloma virus in Shanxi

目的探讨山西地区HPV感染与食管鳞癌发生之间的关系。方法采用原位杂交技术分别对食管鳞癌肿瘤组织和和正常组织进行HPV-DNA基因检测。结果 HPV在食管鳞癌肿瘤组织的检出率明显高于正常组织,并且在高分化鳞癌和中低分化鳞癌中有显著差异,其分化程度与HPV感染呈负相关。结论 HPV病毒感染是食管鳞癌的致瘤因素之一,但可控可防,在病毒感染早期进行干预可一定程度避免其发展为恶性肿瘤。

Objective To explore the relationship between the HPV infection and the esophageal squamous carcinoma in Shanxi region .Methods By using the in‐situ hybridization technology ,the esophageal squamous car‐cinoma tumor tissues and normal tissues were performed by the HPV‐DNA detects respectively？ Results The pos‐itives of HPV‐DNA in esophageal squamous carcinoma tumor tissues was much higher than that of normal tissue , and there were significant differences in the high differentiated squamous carcinoma and middle‐low differentiated squamous carcinoma ,its degree of differentiation has negative correlation with the HPV infection .Conclusion The HPV infection is one of the tumorigenic factors of the esophageal squamous carcinoma ,but preventable and con‐trollable ;The malignant tumor can be avoided to a certaln extent by the early intervention in the virus infection.