肺部给药系统及其治疗肺部疾病的进展

Pulmonary drug delivery systems and progress in their applications to lung disease treatment

肺部给药系统具有肺局部药物浓度高、无首过效应、药物吸收快等优势,已成为肺部疾病治疗和促进大分子药物吸收的重要手段。本文结合肺的生理特点,着重介绍肺吸入给药的剂型、制备方法、质量评价和体内实验方法,以及肺部给药系统在肺部疾病,包括急性肺损伤、肺部感染、肺纤维化、哮喘、慢性阻塞性肺病和肺癌等治疗中的应用。

Pulmonary drug delivery systems （PDDS） have some advantages, including high drug accumulation in the lungs, no first pass effect, and rapid absorption of drugs. They have become a key way to treat lung diseases and improve the absorption of biomacromolecules. In this review, we analyze lung′s physiological features, and discuss the main dosage forms of lung inhalations, their preparation methods, the evaluation methods, and the in vivo experimental methods. The applications of pulmonary drug delivery to lung diseases, including acute lung injury, pulmonary infection, pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, and lung cancer, are also discussed.