靶标代谢组学在不同代谢物群研究中的应用

Application of targeted metabolomics to study different metabolite groups

作为代谢组学的一种研究模式,靶标代谢组学常用于对特定的目标代谢物进行精确定性定量分析,主要研究特定结构功能类型的代谢物群,例如脂类、肉毒碱类、嘌呤嘧啶类或氨基酸类等。代谢物的准确定量将使代谢组学研究更全面更可靠,有助于更清晰地研究疾病机制,达到疾病预警、指导和评价治疗的目的。本文主要介绍了靶标代谢组学技术在不同代谢物群研究中的应用。

As one of the types of metabolomic studies, targeted metabolomics is often used to determine precisely and accurately a limited number of pre-defined metabolites. In targeted metabolomic studies, metabolite groups with different structures and functions, such as lipids, carnitines, purine and pyrimidine, or amino acids, are investigated. Accurate quantification of targeted metabolites can make metabolomic studies more comprehensive and reliable, which is helpful to study the mechanism of diseases and achieve the purpose of disease warning, guidance, evaluation and treatment. In this review, the focus is on the application of targeted metabolomics to study metabolite groups with different structures and functions.