首发精神分裂症患者血清叶酸、同型半胱氨酸与P300的相关性

Correlation between serum folate,homocysteine and P300 in patients with first-episode schizophrenia

目的：研究首发精神分裂症患者血清叶酸及同型半胱氨酸与P300的相关性。方法选取50例首发精神分裂症患者作为患者组，在医院职工和社区人群中选取年龄、性别相匹配的50名健康人作为对照组，分别测定所有被试的血清叶酸及同型半胱氨酸和 P300，应用阳性和阴性症状量表（PANSS）评定患者组入组时精神症状。结果患者组血清叶酸水平低于对照组，差异有统计学意义（t ＝5．14，P ＜0．01）；血清同型半胱氨酸高于对照组，差异有统计学意义（t ＝4．23，P＜0．01）；患者组P300波幅低于对照组而潜伏期高于对照组，差异有统计学意义（ t ＝2．51～3．23，P ＜0．05）。患者组血清叶酸水平与各位点P300波幅及潜伏期均无相关性。患者组血清同型半胱氨酸水平与Cz、Pz位点P300潜伏期呈正相关（ r＝0．36～0．46，P＜0．05），患者组血清同型半胱氨酸水平与Cz、Pz点P300波幅则呈负相关（ r ＝－0．38～－0．51，P＜0．05）。结论首发精神分裂症患者P300的波幅和潜伏期变化可能与血清同型半胱氨酸代谢异常有关，而与血清叶酸水平无直接相关性。

Objective To explore the correlation between serum homocysteine ,folate and P300 in first-episode schizophrenia patients .Methods Fifty patients with first -episode schizophrenia were se‐lected as patient group ,choosing the age and sex -matched 50 healthy people in hospital staff and com‐munity groups as control group ,all participants were sepatately tested serum folate ,homocysteine and P300 ,and assessing psychotic symptoms when patients enrolled by Positive and Negative Syndrome Scale（PANSS） .Results Compared with the control group ,the level of serum folate was lower than in patient group ,the difference was statistically significant （t=5 .14 ,P〈0 .01）;Serum homocysteine was higher than the control group ,the difference was statistically significant （t=4 .23 ,P〈0 .01）;Compared with the control group ,P300 amplitude was lower and the incubation period was higher in patient group , and the difference was statistically significant （t=2 .51 -3 .23 ,P〈0 .05） .In patient group ,serum ho‐mocysteine and Cz ,Pz site of P300 latency was positively correlated （r=0 .36~0 .46 ,P〈0 .05） ,serum homocysteine and Cz ,Pz point of P300 amplitude was negatively correlated （r= -0 .38 - -0 .51 ,P〈0.05） .Conclusions The amplitude and latency of P300＇s changes in first-episode schizophrenia patients may be associated with serum homocysteine metabolism ,and with no direct correlation with serum folate levels .