抑郁症患者儿童期受虐对BDNF水平的影响

Influence of childhood abuse on BDNF levels in patients with depression

目的：探讨抑郁症患者儿童期受虐对血清脑源性神经营养因子（BDNF）水平的影响。方法选取抑郁症患者98例，使用儿童受虐问卷（CTQ）、汉密尔顿抑郁量表（HAMD）、自杀意念量表（SIOSS）及贝克绝望量表（BHS）评定儿童期受虐状况、抑郁严重程度、自杀意念强度和绝望严重程度；根据儿童受虐问卷评分将受试者分为受虐组（32例），无受虐组（66例）。并选择30名健康体检人群作为健康对照组。采用酶联免疫吸附法测定血清BDNF水平。结果依据CTQ评分结果，98例入组患者中32例（32．65％）有儿童期受虐史。儿童期受虐组与无受虐组在首次发病年龄、性别比、HAMD－24总分、BHS总分、SIOSS总分等方面差异均有统计学意义。儿童期受虐组的血清BDNF水平[（627±36）pg／ml]低于无受虐组[（743±28）pg／ml；P＜0．01]和健康对照组[（1320±39）pg／ml；P＜0．01]。无受虐组的BDNF水平低于健康对照组（P＜0．01）。结论抑郁症患者儿童期受虐待对BDNF水平有明显的影响，儿童期受虐导致BDNF水平下降可能是成年后罹患抑郁症的危险因素。

Objective To explore the effects of childhood abuse on serum of BDNF level in pa‐tients with depression .Methods Totals of 98 patients with depression were included in this study .Using Child abuse Questionaire（CTQ） ,Hamilton Depression Scale（HAMD） ,Suicidal Ideation Scale（SIOSS） and Beck Hopelessness Scale（BHS） to assess the situation of childhood abuse ,severity of depression , suicidal ideation and severity of despair ;According to CTQ score ,the subjects were divided into abuse group （n= 32） and non-abused group （n= 66） .And selected 30 healthy people as the control group . The serum of BDNF levels were determined by Enzyme-linked Immunosorbent .Results All 98 cases of patients enrolled in 32（32 .65% ） had a history of childhood abuse .There were significant differences be‐tween the abuse group and the non-abused group in the first onset age ,sex ratio ,the total score of the HAMD-24 ,the total score of BSH and the total score of SIOSS .BDNF levels of abuse group （627 ± 36）pg/ml were lower than those in non -abused group [（743 ± 28）pg/ml;P 〈 0 .01] and the control group [（1 320 ± 39）pg/ml;P〈 0 .01）] .BDNF levels of non -abused group were lower than control group （P〈 0 .01） .Conclusions Depression in patients with childhood abuse has obvious influence on BDNF levels ,childhood abuse led to the decrease of BDNF level may be a risk factor as an adult suffering from depression .