碧兰麻对比利多卡因在牙体牙髓病麻醉中的临床疗效及安全性研究

Clinical efficacy and safety between primacaine and lidocaine for the treatment of tooth pulp disease

目的：探讨碧兰麻与利多卡因在牙体牙髓病麻醉中的临床疗效及安全性。方法将136例牙体牙髓病患者随机分为试验组66例和对照组70例。试验组在患牙唇颊侧根尖区黏膜下注射碧兰麻，单根牙用量0．6～0．8 mL，多根牙用量1．4～1．6 mL。对照组在患牙唇颊侧根尖区黏膜下注射利多卡因2～4 mL。比较2组患者的麻醉起效时间、麻醉效果及不良反应发生率。结果试验组平均麻醉起效时间（2．1±0．6）min显著短于对照组（5．6±1．2）min（P＜0．05）。试验组患者拔髓时的优良率33．33％显著高于对照组15．71％（ P＜0．05）。2组患者不良反应发生率差异无统计学意义（ P＞0．05）。结论碧兰麻用于在牙体牙髓病麻醉起效快、镇痛效果显著，不良反应轻微。

Objective To evaluate the efficacy and safety between pri-macaine and lidocanie on tooth pulp disease.Method A total of 136 cases of tooth pulp disease were included in this study from August 2013 to June 2014 in our hospital and were divided into the treatment group （66 cases） and control group （70 cases） .Patients in the treatment group were given primacaine 0.6 -0.8 mL for single tooth root and 1.4-1.6 mL for multiple roots.And patients in control group were given lidocanie 2 -4 mL.The data of anesthesia function time, anesthetic effect, and adverse drug reactions in the two groups were analyzed. Results The mean function time was （ 2.1 ± 0.6 ） min and （5.6 ±1.2） min in the treatment and control group, respectively （ P〈0.05）.The excellent rate was 33.33%and 15.71%in the treatment and control group, respectively with statistical difference （ P〈0.05）.But the adverse drug reactions between the two groups had not statistical difference（P〉0.05）.Conclusion Primacaine for the treatment of tooth pulp disease has a fast response time, a good anaesthesia effect and less adverse reaction.