二氧化碳结合间苯三酚在结肠镜检查中的镇痛疗效与安全性评价

Analgesic efficacy and safety of phloroglucinol in patients during coloscopy

目的评价二氧化碳结合间苯三酚在结肠镜检查中对患者的阵痛疗效及安全性。方法入选进行结肠镜检查的患者164例,分为试验组88例和对照组76例。2组患者检查前3 d进食易消化食物,12 h和6 h前分次口服聚乙二醇电解质散清洁肠道,用二氧化碳作为肠镜检查的膨胀气体。试验组检查前10 min肌内注射间苯三酚40 mg,对照组肌内注射0.9%氯化钠2 m L。2组患者用视觉模拟评分(VAS)记录结肠镜检查过程中的疼痛评分,并观察2组患者结肠镜达到盲肠的例数及检查前、检查中和检查后血压及心率变化。结果试验组和对照组检查过程中VAS疼痛评分分别为(4.1±1.4)和(6.3±1.5),试验组显著低于对照组(P<0.05)。试验组结肠镜达到盲肠者80例,达盲率为90.9%,对照组结肠镜达到盲肠者68例,达盲率为89.5%,差异无统计学意义(P>0.05)。试验组与对照组结肠镜检查前、检查中及检查后收缩压、舒张压及心率差异均无统计学意义(P>0.05)。结论用二氧化碳作为肠镜检查的膨胀气体,同时术前肌内注射间苯三酚可显著减轻患者结肠镜检查过中的疼痛,且无明显不良反应发生。

Objective To evaluate the clinical efficacy and safety of phloroglucinol in patients during coloscopy.Methods A total of 164 patients who were prepared for coloscopy were randomized divided into experiment group （ n =88 ） and control group （ n =76 ） . All of the patients in the two groups were given food easy to digest 3 days before coloscopy and given polyethylene glycol electrolyte powder orally 12 and 6 hours before coloscopy.The carbom dioxide was used as the expansion of the gas, and patients in the experiment group were given phloro-glucinol 40 mg by intramuscular injection 10 minutes before the colosco-py, and those in the control group were given 0.9%NaCl 2 mL by intra-muscular injection.The data of visual analogue score（ VAS） , rate of co-loscopy examination reached to the cecum, blood pressure and heart rate before and after the examination between the two groups were recorded. Results The VAS score were （ 4.1 ±1.4 ） and （ 6.3 ±1.5 ） points in the experiment and control group respectively, with experiment group significantly lower than the control group （ P〈0.05 ） .The reach cecum rate was 90.9%in experiment group and 89.5%in control group, which indicated no statistical difference between the two groups （ P〉0.05 ） .The blood pressure and heart rate of the two groups were not statistically different in the procedure of coloscopy （P〉0.05）.Conclusion Phloroglucinol can significantly decrease the VAS in the procedure of coloscopy, without increasing the incidence of adverse drug reactions.